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Review
. 2024 Dec;16(6):2229-2250.
doi: 10.1007/s12602-024-10338-9. Epub 2024 Aug 5.

The Immunomodulatory Effects and Applications of Probiotic Lactiplantibacillus plantarum in Vaccine Development

Guiting He  1 , Huanbing Long  1 , Jiarong He  1 , Cuiming Zhu  2
Affiliations
Review

The Immunomodulatory Effects and Applications of Probiotic Lactiplantibacillus plantarum in Vaccine Development

Guiting He et al. Probiotics Antimicrob Proteins. 2024 Dec.

Abstract

Lactiplantibacillus plantarum (previously known as Lactobacillus plantarum) is a lactic acid bacterium that exists in various niches. L. plantarum is a food-grade microorganism that is commonly considered a safe and beneficial microorganism. It is widely used in food fermentation, agricultural enhancement, and environmental protection. L. plantarum is also part of the normal flora that can regulate the intestinal microflora and promote intestinal health. Some strains of L. plantarum are powerful probiotics that induce and modulate the innate and adaptive immune responses. Due to its outstanding immunoregulatory capacities, an increasing number of studies have examined the use of probiotic L. plantarum strains as natural immune adjuvants or alternative live vaccine carriers. The present review summarizes the main immunomodulatory characteristics of L. plantarum and discusses the preliminary immunological effects of L. plantarum as a vaccine adjuvant and delivery carrier. Different methods for improving the immune capacities of recombinant vector vaccines are also discussed.

Keywords: Lactiplantibacillus plantarum; Adjuvant; Immune effect; Probiotic; Vaccine vector.

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Conflict of interest statement

Declarations Conflict of Interest The authors declare no competing interests.

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