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. 2024 Oct 1;178(10):1072-1074.
doi: 10.1001/jamapediatrics.2024.2507.

Early Circulating Biomarkers of Language Development in Single Ventricle Heart Disease

Kelly R Wolfe  1 , Lindsay M Thomson  1 , Sierra Niemiec  2 , Christopher A Mancuso  2 , Ludmila Khailova  1 , Benjamin S Frank  1 , Jesse A Davidson  1
Affiliations

Early Circulating Biomarkers of Language Development in Single Ventricle Heart Disease

Kelly R Wolfe et al. JAMA Pediatr. .
No abstract available

Plain language summary

This cohort study assesses proteins measured in infancy and neurodevelopmental outcomes in single ventricle heart disease.

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Conflict of interest statement

Dr Thomson reported receiving grants from National Institutes of Health StARR scholarship and grant program during the conduct of the study. Dr Mancuso reported receiving grants from the National Institutes of Health (NIH) during the conduct of the study. Dr Davidson reported receiving grants from the NIH, from the American Heart Association (AHA), and from Additional Ventures during the conduct of the study. No other disclosures were reported.

Figures

Figure.
Figure.. Functions of Proteins Associated With Toddler-Age Language Scores Following False Discovery Rate Correction
The dependent variable is the Language Index Standard Score from the Bayley Scales of Infant and Toddler Development, Fourth Edition (BSID-4). BOC indicates brother of CDO (cell adhesion molecule-related/downregulated by oncogenesis); BSG, basigin; CNTN, contactin; CTHRC1, collagen triple helix repeat containing 1; DLL4, delta like canonical notch ligand 4; EFNA4, EPH-related receptor tyrosine kinase ligand 4; EGFR, epidermal growth factor receptor; EPHA1, ephrin type-A receptor 1; FLRT2, fibronectin leucine-rich repeat transmembrane protein2; LRPAP, LDL receptor-related protein-associated protein; LTBP4, latent transforming growth factor beta binding protein4; NEFL, neurofilament light polypeptide; NOTCH, notch receptor; NRP2, neuropilin 2; NTRK, neurotrophic receptor tyrosine kinase2; OMG, oligodendrocyte myelin glycoprotein; PTPRS, protein tyrosine phosphatase receptor type S; RET, receptor tyrosine kinase; ROBO2, roundabout guidance receptor 2; TIMP2, tissue inhibitor of metalloproteinases 2; TNC, tenascin C. This image was created with Biorender.com. aUpregulation of this protein (NEFL) was associated with higher BSID-4 language scores. For all other proteins, downregulation was associated with higher BSID-4 language scores.
See this image and copyright information in PMC

References

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