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. 2024 Oct 17;144(16):1747-1751.
doi: 10.1182/blood.2024024351.

Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS

Esteban Arrieta-Bolaños  1   2 , Lars L J van der Burg  3 , Tobias Gedde-Dahl  4 , Marie Robin  5 , Urpu Salmenniemi  6 , Nicolaus Kröger  7 , Ibrahim Yakoub-Agha  8 , Anne Huynh  9 , Charles Crawley  10 , Eric Deconinck  11 , Claude Eric Bulabois  12 , Edouard Forcade  13 , Eleni Tholouli  14 , Joost G K van der Hem  15 , Peter van Balen  15 , Jorinde D Hoogenboom  16 , Liesbeth C de Wreede  3   17 , Florent Malard  18   19 , Annalisa Ruggeri  19 , Katharina Fleischhauer  1   2
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Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS

Esteban Arrieta-Bolaños et al. Blood. .

Abstract

HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and noncore subsets. Noncore permissive graft-versus-host mismatches show significantly reduced risks of relapse without increased nonrelapse mortality compared with allele-matched pairs.

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