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Review
. 2025 Sep;93(3):585-600.
doi: 10.1016/j.jaad.2024.05.103. Epub 2024 Aug 3.

Cutaneous Diseases of Penoscrotal Skin-Part I: Benign and Neoplastic Lesions

Affiliations
Review

Cutaneous Diseases of Penoscrotal Skin-Part I: Benign and Neoplastic Lesions

Michael J Martinez et al. J Am Acad Dermatol. 2025 Sep.

Abstract

Penoscrotal skin diseases encompass an array of pathologies that present with unique clinical features. A patient-tailored approach to management is necessary. This article, part of a continuing medical education series, is dedicated to offering insights for managing penoscrotal dermatoses. The first article will provide an overview of normal variations, benign lesions, and malignant growths. We will then highlight up-to-date diagnostic and treatment protocols. In the second article, we will discuss inflammatory and infectious conditions, reviewing common diseases such as syphilis, human papillomavirus, and psoriasis, as well as rarer, difficult to treat diseases such as lichen sclerosus, lichen planus, and genital dyesthesias. Considering 70% of patients with genital skin diseases report that physicians lack awareness of these conditions, this continuing medical education (CME) Education series will help practitioners identify penoscrotal diseases, expand differential diagnoses, and discuss appropriate and emerging therapies.

Keywords: Fordyce spots; PeIN; angiokeratomas; extramammary Paget's disease; lichen sclerosus; male genital cutaneous diseases; median raphe cyst; pearly penile papules; penile intraepithelial neoplasia; penile melanoma; penile skin diseases; penile squamous cell carcinoma; penoscrotal disease; scrotal calcinosis; scrotal skin diseases.

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Conflict of interest statement

Conflicts of interest Dr Zampella has served on advisory boards for Dermavant and Janssen Pharmaceuticals. Drs Martinez, Oh, Young, Meehan, and Hall have no conflicts of interest to declare.

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