Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 5;14(1):18098.
doi: 10.1038/s41598-024-69169-x.

Link between remnant cholesterol and the reversion to normoglycemia in Chinese adults with prediabetes: a 5-year cohort study

Weifeng Chen #  1 , Haofei Hu #  2 , Changchun Cao #  3 , Dehong Liu  4 , Yong Han  5
Affiliations

Link between remnant cholesterol and the reversion to normoglycemia in Chinese adults with prediabetes: a 5-year cohort study

Weifeng Chen et al. Sci Rep. .

Abstract

Despite the clear association between remnant cholesterol (RC)and diabetes risk, no study to date has examined the relationship between RC and reversal of prediabetes to normoglycemia. This retrospective cohort study included a total of 15,023 patients with prediabetes who underwent a physical examination between 2010 and 2016. The link between initial RC levels and the reversion from prediabetes to normoglycemia was analyzed using the Cox proportional-hazards regression model. Additionally, the study explored the possible relationship between RC and the probability of returning normoglycemia by applying Cox proportional hazards regression models with cubic spline functions. To address competing risks, a multivariate Cox regression analysis was undertaken, treating the onset of diabetes as a competing risk event for reversing prediabetes to normoglycemia. Additionally, the study incorporated extensive subgroup analyses alongside multiple sensitivity analyses, enhancing the reliability and robustness of the results. After adjusting for covariates, the findings indicated that RC was inversely associated with the likelihood of reverting to normoglycemia (per 5 mg/dL increase, HR = 0.918, 95% CI 0.909-0.927). The analysis also revealed a nonlinear relationship between RC and normoglycemia reversion, with an inflection point at 51.08 mg/dL. For RC values below this inflection point (RC < 50.08 mg/dL), the HR for the probability of returning to normoglycemia was 0.907 (95% CI 0.897-0.917 per 5 mg/dL). Additionally, the competing risks model demonstrated a negative relationship between RC and the reversal of prediabetes to normoglycemia (SHR = 0.92, 95% CI 0.91-0.93). Sensitivity analyses confirmed the robustness and stability of these results. This study demonstrated a negative and non-linear association between RC and the probability of reversion to normoglycemia in Chinese adults with prediabetes. By actively intervening to reduce RC levels, at least to below 51.08 mg/dL, further reduction of RC may significantly increase the probability of returning to normoglycemia from prediabetes.

Keywords: Competing risks model; Non-linear; Prediabetes; Remnant cholesterol; Reversion to normoglycemia.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Overview of the process used for screening study participants.
Figure 2
Figure 2
Distribution of RC. This figure presented RC was normally distributed between 0.39 and 89.40 with a mean value of 29.25 mg/l.
Figure 3
Figure 3
Probability density function plot of RC for the reversal to normoglycemia and non-reversal to normoglycemia groups in Pre-DM.
Figure 4
Figure 4
The Kaplan–Meier curves for reversion from prediabetes to normoglycemia stratified by RC quartiles.
Figure 5
Figure 5
Non-linear relationship between RC and the probability of returning to normoglycemia from Pre-DM.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Echouffo-Tcheugui, J. B., Perreault, L., Ji, L. & Dagogo-Jack, S. Diagnosis and management of prediabetes: A review. JAMA J. Am. Med. Assoc.329, 1206–1216 (2023).10.1001/jama.2023.4063 - DOI - PubMed
    1. Herman, W. H. Prediabetes diagnosis and management. JAMA J. Am. Med. Assoc.329, 1157–1159 (2023).10.1001/jama.2023.4406 - DOI - PubMed
    1. Classification and Diagnosis of Diabetes. Standards of medical care in diabetes-2022. Diabetes Care45, S17–S38 (2022). 10.2337/dc22-S002 - DOI - PubMed
    1. Sun, H. et al. Idf Diabetes atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res. Clin. Pract.183, 109119 (2022). 10.1016/j.diabres.2021.109119 - DOI - PMC - PubMed
    1. Garber, A. J. et al. Diagnosis and management of prediabetes in the continuum of hyperglycemia: When do the risks of diabetes begin? A consensus statement from the American College of Endocrinology and the American Association of Clinical Endocrinologists. Endocr. Pract.14, 933–946 (2008). 10.4158/EP.14.7.933 - DOI - PubMed

LinkOut - more resources