Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov;50(1):339-340.
doi: 10.1038/s41386-024-01945-9.

Precision functional mapping for target engagement in drug development

Joshua S Siegel  1   2
Affiliations

Precision functional mapping for target engagement in drug development

Joshua S Siegel. Neuropsychopharmacology. 2024 Nov.

Erratum in

No abstract available

PubMed Disclaimer

Conflict of interest statement

JSS is co-author of a provisional patent (Patent 020949/US 15060-1787) for the use of precision functional mapping for measuring target engagement by experimental therapeutics. Within the last year, JSS was an employee of Sumitomo Pharma America and received consulting fees from Longitude Capital. These potential conflicts of interest have been reviewed and are managed by Washington University School of Medicine.

References

    1. Laumann TO, Gordon EM, Adeyemo B, Snyder AZ, Joo SJ, Chen M-Y, et al. Functional system and areal organization of a highly sampled individual human brain. Neuron. 2015;87:657–70. - PMC - PubMed
    1. Gordon EM, Laumann TO, Gilmore AW, Newbold DJ, Greene DJ, Berg JJ, et al. Precision functional mapping of individual human brains. Neuron. 2017;95:791–807.e7. - PMC - PubMed
    1. Newbold DJ, Laumann TO, Hoyt CR, Hampton JM, Montez DF, Raut RV, et al. Plasticity and spontaneous activity pulses in disused human brain circuits. Neuron. 2020;107:580–9.e6. - PMC - PubMed
    1. Siddiqi SH, Kandala S, Hacker CD, Bouchard H, Leuthardt EC, Corbetta M, et al. Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury. Sci Transl Med. 2023;15:eabn0441. - PubMed
    1. Keller AS, Pines AR, Shanmugan S, Sydnor VJ, Cui Z, Bertolero MA, et al. Personalized functional brain network topography is associated with individual differences in youth cognition. Nat Commun. 2023;14:8411. - PMC - PubMed

LinkOut - more resources