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Review
. 2024 Dec 31;20(1):2378543.
doi: 10.1080/21645515.2024.2378543. Epub 2024 Aug 5.

Approved CAR-T therapies have reproducible efficacy and safety in clinical practice

Daniel Goyco Vera  1 , Hiral Waghela  1 , Mohamed Nuh  1 , Jonathan Pan  1 , Premal Lulla  1   2
Affiliations
Review

Approved CAR-T therapies have reproducible efficacy and safety in clinical practice

Daniel Goyco Vera et al. Hum Vaccin Immunother. .

Abstract

CAR-T cell therapy has established itself as a highly effective treatment for hematological malignancies. There are currently six commercial CAR-T products that have been FDA approved for diseases such as B-ALL, LBCL, MCL, FL, MM, and CLL/SLL. "Real-world" studies allow us to evaluate outcomes from the general population to determine their efficacy and safety compared to those who were included in the original trials. Based on several well conducted "Real-world" studies that represent diverse populations, we report that outcomes from the original trials that led to the approval of these therapies are comparable to those in practice.

Keywords: CAR-T; CAR-T efficacy; CAR-T outcomes; CAR-T real-world; CAR-T safety; chimeric antigen receptor T-cell therapy outcomes.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

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