Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jul 24:2024:7310135.
doi: 10.1155/2024/7310135. eCollection 2024.

T-PLL Presenting with an Indolent Course

Arsa Thammahong  1   2 , Narittee Sukswai  3 , Chantana Polprasert  1   4
Affiliations
Case Reports

T-PLL Presenting with an Indolent Course

Arsa Thammahong et al. Case Rep Hematol. .

Abstract

T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell leukemia which usually presents with aggressive behavior. We report an asymptomatic T-PLL patient diagnosed by clinical features, lymphocyte morphology, and flow cytometry. Incidentally, she was found to have lymphocytosis and lymphadenopathy. Flow cytometry from blood revealed an abnormally increased CD4+ T-cell population. T-cell receptor clonality assessment by next-generation sequencing revealed a dominant clone in the ß-chain constant region. No pathogenic mutations in 25 lymphoma-related genes were found. Due to her asymptomatic T-PLL disease, we observed her clinical situation and blood count every three months for at least one year.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Peripheral blood smear showed increased small to medium-sized mature lymphocytes. (a) 100x; (b) 1,000x.
Figure 2
Figure 2
Flow cytometry from peripheral blood. (a) R represents lymphocyte gate and is further analyzed in (b)–(d).
Figure 3
Figure 3
Immunohistochemistry of bone marrow biopsy showed CD3 and TCR-b positive with aberrant loss of CD7. (a) H&E (x400). (b) CD3 (x400). (c) CD7 (x400). (d) TCR-b (x400).
Figure 4
Figure 4
Results from next-generation sequencing showed a dominant clone of TRBV6-5 (90.28%).
See this image and copyright information in PMC

References

    1. Matutes E., Brito-Babapulle V., Swansbury J., et al. Clinical and laboratory features of 78 cases of T-prolymphocytic leukemia. Blood . 1991;78(12):3269–3274. doi: 10.1182/blood.v78.12.3269.bloodjournal78123269. - DOI - PubMed
    1. Alaggio R., Amador C., Anagnostopoulos I., et al. The 5th edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia . 2022;36(7):1720–1748. doi: 10.1038/s41375-022-01620-2. - DOI - PMC - PubMed
    1. Hallek M., Cheson B. D., Catovsky D., et al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood . 2018;131(25):2745–2760. doi: 10.1182/blood-2017-09-806398. - DOI - PubMed
    1. Garand R., Goasguen J., Brizard A., et al. Indolent course as a relatively frequent presentation in T‐prolymphocytic leukaemia. British Journal of Haematology . 1998;103(2):488–494. doi: 10.1046/j.1365-2141.1998.00977.x. - DOI - PubMed
    1. Mahe E., Pugh T., Kamel-Reid S. T cell clonality assessment: past, present and future. Journal of Clinical Pathology . 2018;71(3):195–200. doi: 10.1136/jclinpath-2017-204761. - DOI - PMC - PubMed

Publication types

LinkOut - more resources