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Case Reports
. 2024 Jul 6;16(7):e63969.
doi: 10.7759/cureus.63969. eCollection 2024 Jul.

Hyperdiluting Calcium Hydroxylapatite With Platelet-Rich Plasma and Hyaluronidase for Improving Neck Laxity and Wrinkle Severity

Saami Khalifian  1 , Alec D McCarthy  2   3 , Steven G Yoelin  4
Affiliations
Case Reports

Hyperdiluting Calcium Hydroxylapatite With Platelet-Rich Plasma and Hyaluronidase for Improving Neck Laxity and Wrinkle Severity

Saami Khalifian et al. Cureus. .

Abstract

The two cases discussed in this report investigate the efficacy and safety of a novel injectable therapy for treating neck wrinkles and skin laxity, utilizing a combination of hyperdiluted calcium hydroxylapatite (CaHA), platelet-rich plasma (PRP), and hyaluronidase. Two patients presenting with moderate neck wrinkles and laxity underwent treatment and were evaluated several months later. The combined therapy demonstrated improvements in skin texture and laxity following a single treatment. The rationale behind incorporating PRP and hyaluronidase was their potential to amplify the regenerative effects of CaHA. PRP contains growth factors that stimulate collagen production and tissue regeneration while hyaluronidase facilitates the breakdown of hyaluronic acid, promoting better diffusion and more even product dispersion. The findings from these cases provide emerging preliminary evidence supporting the safety and efficacy of this innovative combination therapy for addressing neck wrinkles and laxity. This is the first documented instance of skin priming CaHA with hyaluronidase and PRP. Future investigations are warranted to explore the application of this treatment for other anatomical regions and to delineate the role of each injected component.

Keywords: aesthetic medicine; caha; calcium hydroxylapatite; cosmetic dermatology; hyaluronidase; platelet rich plasma; prp; radiesse; regenerative aesthetics.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: Steven Yoelin declare(s) employment from Steve Yoelin MD Associates. Steven Yoelin is employed by Steve Yoelin MD Associates and performs this procedure as an offered service in his routine practice. Alec D McCarthy declare(s) employment from Merz Aesthetics. Alec McCarthy is employed by Merz Aesthetics. Saami Khalifian Steven Yoelin declare(s) personal fees from Merz Aesthetics. Saami Khalifian and Steven Yoelin are paid trainers, speakers, and investigators for Merz Aesthetics. Saami Khalifian, Steven Yoelin declare(s) personal fees from Allergan Aesthetics. Saami Khalifian is a paid speaker, trainer, and investigator for Allergan Aesthetics. Steve Yoelin is a paid researcher and speaker for Allergan Aesthetics. Saami Khalifian declare(s) personal fees from Galderma. Saami Khalifian is a paid trainer, speaker, and investigator for Galderma. Steven Yoelin declare(s) personal fees from Revance Aesthetics. Steven Yoelin is a paid researcher for Revance Aesthetics. Steven Yoelin declare(s) personal fees from RVL. Steven Yoelin is a paid researcher for RVL. Steven Yoelin declare(s) personal fees from Suneva Aesthetics. Steven Yoelin is a paid researcher and consultant for Suneva Aesthetics. Saami Khalifian declare(s) employment from SOM Aesthetics. Saami Khalifian is employed by SOM Aesthetics and performs this procedure as an offered service in his routine practice. Other relationships: Saami Khalifian and Steven Yoelin are practicing physicians who offer this treatment to patients in their private medical practices.

Figures

Figure 1
Figure 1. Preparation and protocol for neck treatment with CaHA-CMC/PRP
(A) The components of a single syringe of treatment consisting of 5 ml autologous PRP, 1.5 ml CaHA-CMC, and 1 ml hyaluronidase; (B) The method for homogenizing the mixture (the resultant color of the solution is a light orange color); (C) The injection pattern used for both patients Figure credits: Original image created by the authors
Figure 2
Figure 2. A 56-year-old patient 4 months after undergoing the described CaHA-CMC/PRP treatment
CaHA-CMC: calcium hydroxylapatite-carboxymethylcellulose; PRP: platelet-rich plasma
Figure 3
Figure 3. Figure 3. A 72-year-old patient 3 months after undergoing the described CaHA-CMC/PRP treatment
CaHA-CMC: calcium hydroxylapatite-carboxymethylcellulose; PRP: platelet-rich plasma
See this image and copyright information in PMC

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