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Review
. 2024 Sep:59 Suppl 1:S27-S35.
doi: 10.1002/ppul.27163.

Overnutrition in persons with cystic fibrosis on modulator therapy and the relationship to obstructive sleep apnea

Aesha M Jobanputra  1 , Keerthana Kesavarapu  2 , Sreelatha Naik  3 , Maya Ramagopal  4 , Matthew T Scharf  1   5 , Sugeet Jagpal  1
Affiliations
Review

Overnutrition in persons with cystic fibrosis on modulator therapy and the relationship to obstructive sleep apnea

Aesha M Jobanputra et al. Pediatr Pulmonol. 2024 Sep.

Abstract

Cystic fibrosis (CF) care is evolving with the ubiquitous use of modulator therapy and resultant increase in lifespan. It is important for CF clinicians to monitor the pathologic weight gain that is concomitantly being seen as obesity is a known risk factor for multiple other diseases. In this review we focus on obesity in CF, discuss screening and lifestyle considerations, outline CF-specific concerns with weight loss medications, and describe the vicious cycle of obesity and obstructive sleep apnea (OSA). We discuss screening and treatment for OSA, as it directly correlates with weight fluctuation. We offer interim recommendations for CF teams as they continue to care for this population.

Keywords: cystic fibrosis; modulators; obesity; obstructive sleep apnea; pharmacotherapy.

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References

REFERENCES

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MeSH terms

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