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Meta-Analysis
. 2025 Jan;46(1):303-312.
doi: 10.1007/s10072-024-07724-0. Epub 2024 Aug 6.

Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis

Martina Giacon  1 , Sarah Cargnin  2 , Marta Allena  3 , Rosaria Greco  3 , Anna Maria Zanaboni  3   4 , Sara Facchetti  3   4 , Roberto De Icco  3   4 , Grazia Sances  3 , Natascia Ghiotto  3 , Elena Guaschino  3 , Daniele Martinelli  3   4 , Cristina Tassorelli  3   4 , Salvatore Terrazzino  5
Affiliations
Meta-Analysis

Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis

Martina Giacon et al. Neurol Sci. 2025 Jan.

Abstract

Objective: To confirm a previously reported association of TRPV1 rs8065080 with the risk of transformation from episodic (EM) to chronic migraine (CM) and to extend knowledge about the role of other TRPV1 single nucleotide polymorphisms (SNPs), we first investigated the impact of three TRPV1 SNPs (rs8065080, rs222747 and rs222749) on the risk of migraine chronification in a case-control study. A systematic review and meta-analysis were then conducted to summarize the accumulated findings.

Methods: Genotyping of the selected TRPV1 SNPs was performed using TaqMan real-time PCR in 167 EM and 182 CM participants. Crude and adjusted odds ratios with associated 95% confidence intervals were calculated in the log-additive, dominant, and recessive genetic models. A comprehensive literature search was performed in PubMed, Web of Knowledge, Cochrane Library, and OpenGrey until February 2024.

Results: In our case-control study, no association was found between TRPV1 SNPs and the risk of migraine chronification, both in the unadjusted logistic regression models and after adjustment for confounding clinical variables. The results of the meta-analysis with a total of 241 participants with EM and 223 with CM confirmed no association between TRPV1 SNPs and the risk of migraine chronification in any of the genetic models tested.

Conclusion: The results of the present case-control study and meta-analysis exclude a major role of TRPV1 rs8065080, rs222747, and rs222749 as risk factors for migraine chronification. However, further research is needed to investigate the gene-gene and gene-environment interactions of TRPV1 SNPs on the risk of transformation from episodic to chronic migraine.

Keywords: Chronic migraine; Episodic migraine; Meta-analysis; TRPV1, polymorphism.

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Conflict of interest statement

Declarations. Ethical statement: The study was performed in accordance with the guidelines of the Declaration of Helsinki. Authors obtained local ethics committee approval of the protocol (N°20180034973). Conflict of interest: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the literature search and selection process for eligible studies
Fig. 2
Fig. 2
Forest plots for the association between TRPV1 rs8065080 and migraine chronification under the allelic (A), dominant (B), or recessive (C) genetic models of inheritance
See this image and copyright information in PMC

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