Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201

Jordan R Hansford¹, Gauthier Bouche², Vijay Ramaswamy^{3

4

5}, Nada Jabado⁶, Adriana Fonseca⁷, Sam Moloney⁸, Nicholas G Gottardo⁹, Giles W Robinson¹⁰, Amar Gajjar¹⁰, Christopher L Tinkle¹⁰, Paul G Fisher¹¹, Nicholas Foreman¹², David M Ashley¹³, David S Ziegler^{14

15

16}, David D Eisenstat¹⁷, Maura Massimino¹⁸, Olaf Witt^{19

20

21

22}, Ute Bartels¹⁹, Stefan Rutkowski²³, Darren Hargrave²⁴, Maryam Fouladi²⁵, Stefan M Pfister¹⁹, Eric Bouffet²⁶

Affiliations

¹ Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital; South Australia Health and Medical Research Institute; South Australia ImmunoGENomics Cancer Institute, University of Adelaide, Adelaide, Australia.
² The Anticancer Fund, Meise, Belgium.
³ Developmental and Stem Cell Biology, Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
⁴ Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
⁵ Departments of Medical Biophysics and Pediatrics, University of Toronto, Toronto, ON, Canada.
⁶ Department of Pediatrics, McGill University, RI-MUHC, Montreal, QC, Canada.
⁷ Children's National Hospital, Washington, DC.
⁸ Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute, Melbourne, VIC, Australia.
⁹ Department of Pediatric and Adolescent Oncology and Hematology, Perth Children's Hospital; Telethon Kid's Cancer Centre, Telethon Kid's Institute, University of Western Australia, Perth, WA, Australia.
¹⁰ St Jude Children's Research Hospital, Memphis, TN.
¹¹ Stanford University, Palo Alto, CA.
¹² Colorado Children's Hospital, Denver, CO.
¹³ Preston Robert Tisch Brain Tumor Centre, Duke University, Durham, NC.
¹⁴ Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.
¹⁵ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, NSW, Australia.
¹⁶ Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.
¹⁷ Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute; Department of Pediatrics, University of Melbourne, Melbourne, VIC, Australia.
¹⁸ Pediatric Oncology Unit, Fondazione IRCCS Instituto Nazionale dei Tumori, Milan, Italy.
¹⁹ Hopp Children's Cancer Centre Heidelberg (KiTZ), Heidelberg, Germany.
²⁰ Department of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer 36 Consortium (DKTK), Heidelberg, Germany.
²¹ Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.
²² National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
²³ University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²⁴ UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
²⁵ Department of Neuro-Oncology, Nationwide Children's Hospital, Columbus, OH.
²⁶ The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

PMID: 39110925
DOI: 10.1200/JCO.24.00709

Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201

Jordan R Hansford et al. J Clin Oncol. 2024.

. 2024 Dec 10;42(35):4126-4129.

doi: 10.1200/JCO.24.00709. Epub 2024 Aug 7.

Authors

Affiliations

¹ Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital; South Australia Health and Medical Research Institute; South Australia ImmunoGENomics Cancer Institute, University of Adelaide, Adelaide, Australia.
² The Anticancer Fund, Meise, Belgium.
³ Developmental and Stem Cell Biology, Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
⁴ Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
⁵ Departments of Medical Biophysics and Pediatrics, University of Toronto, Toronto, ON, Canada.
⁶ Department of Pediatrics, McGill University, RI-MUHC, Montreal, QC, Canada.
⁷ Children's National Hospital, Washington, DC.
⁸ Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute, Melbourne, VIC, Australia.
⁹ Department of Pediatric and Adolescent Oncology and Hematology, Perth Children's Hospital; Telethon Kid's Cancer Centre, Telethon Kid's Institute, University of Western Australia, Perth, WA, Australia.
¹⁰ St Jude Children's Research Hospital, Memphis, TN.
¹¹ Stanford University, Palo Alto, CA.
¹² Colorado Children's Hospital, Denver, CO.
¹³ Preston Robert Tisch Brain Tumor Centre, Duke University, Durham, NC.
¹⁴ Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.
¹⁵ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Kensington, NSW, Australia.
¹⁶ Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia.
¹⁷ Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute; Department of Pediatrics, University of Melbourne, Melbourne, VIC, Australia.
¹⁸ Pediatric Oncology Unit, Fondazione IRCCS Instituto Nazionale dei Tumori, Milan, Italy.
¹⁹ Hopp Children's Cancer Centre Heidelberg (KiTZ), Heidelberg, Germany.
²⁰ Department of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer 36 Consortium (DKTK), Heidelberg, Germany.
²¹ Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.
²² National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
²³ University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²⁴ UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
²⁵ Department of Neuro-Oncology, Nationwide Children's Hospital, Columbus, OH.
²⁶ The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

PMID: 39110925
DOI: 10.1200/JCO.24.00709

Abstract

Our international team highlights issues with efficacy reports in several studies on DMG with the new drug ONC201.

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Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201

Affiliations

Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201

Authors

Affiliations

Abstract

MeSH terms

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LinkOut - more resources

Full Text Sources

Medical