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Clinical Trial
. 1985 Dec;23(4):395-400.
doi: 10.1016/0304-3959(85)90010-7.

Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study

Francisco J Gomez-Perez  1 , Juan A Rull, Haroldo Dies, Guillermo J Rodriguez-Rivera, Jorge Gonzalez-Barranco, Oscar Lozano-Castañeda
Affiliations
Clinical Trial

Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study

Francisco J Gomez-Perez et al. Pain. 1985 Dec.

Abstract

A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The differences were statistically significant. Side effects were frequent but not usually severe enough to lead to cessation of these medications.

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