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Comparative Study
. 1985 Jun;33(5 Pt 2):545-9.

[Bacteriostatic and bactericidal effect of cefotaxime combinations on Staphylococcus aureus assessed by FIC and FBC-index determination]

[Article in French]
  • PMID: 3911153
Comparative Study

[Bacteriostatic and bactericidal effect of cefotaxime combinations on Staphylococcus aureus assessed by FIC and FBC-index determination]

[Article in French]
A Reynaud et al. Pathol Biol (Paris). 1985 Jun.

Abstract

Activity of cefotaxime associated with one of nine other antibiotics (amikacin, dibekacin, gentamicin, netilmicin, sisomicin, tobramycin, erythromycin, clindamycin, and chloramphenicol) was studied by a checkerboard method with determination of FIC and FBC-indices. Four S. aureus strains were used: one homogeneous methicillin-resistant strain (S1), one heterogeneous methicillin-resistant strain (S2), and two susceptible strains (S3 and S4). Strong synergism between cefotaxime and aminoglycosides was found only for S2, with no significant differences between aminoglycosides (index # 0.3). Cefotaxime and chloramphenicol showed synergistic or additive bacteriostatic activities and consistently antagonist bactericidal activities. Bactericidal activities of cefotaxime and erythromycin were likewise antagonistic, whereas cefotaxime and clindamycin occasionally exhibited in vitro synergism.

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