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Review
. 2024 Sep;38(3):531-557.
doi: 10.1016/j.idc.2024.06.007.

Cancer in People with HIV

Thomas A Odeny  1 , Valeria Fink  2 , Mazvita Muchengeti  3 , Satish Gopal  4
Affiliations
Review

Cancer in People with HIV

Thomas A Odeny et al. Infect Dis Clin North Am. 2024 Sep.

Abstract

We review the intersection of human immunodeficiency virus (HIV) and cancer globally, including the complex interplay of oncogenic infections, chronic inflammation, and behavioral and other factors in increasing cancer risk among people with HIV (PWH). We discuss current cancer screening, prevention, and treatment recommendations for PWH. Specific interventions include vaccination, behavioral risk reduction, timely HIV diagnosis and treatment, screening for specific cancer sites, and multifaceted treatment considerations unique to PWH including supportive care and drug interactions. Finally, the potential of novel therapies and the need for inclusive cancer clinical trials are highlighted. Collaborative multidisciplinary efforts are critical for continued progress against cancer among PWH.

Keywords: Acquired immunodeficiency disease defining cancers; Cancer in people with human immunodeficiency virus; Human immunodeficiency virus malignancies; Human immunodeficiency virus-associated cancers.

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Conflict of interest statement

Disclosure T.A. Odeny received grant funding from Gilead Sciences. V. Fink participated as speaker and expert discussant for MSD. The opinions expressed in this article are the authors own and do not reflect the view of the NIH, the Department of Health and Human Services, or the United States Government.

Figures

Figure 1:
Figure 1:
The complex and intersecting social, structural, behavioral, and lifestyle factors that affect cancer risk for people with HIV. EBV=Epstein-Barr virus. HPV=human papillomavirus. KSHV=Kaposi sarcoma-associated herpesvirus.
See this image and copyright information in PMC

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