Declaration of competing interest Dr. Rosenthal: Dr. Rosenthal receives research funding support from the NINDS, the Daniel B. and Florence E. Green Family Foundation, the Macks Family Foundation, and the National Ataxia Foundation. She receives additional programmatic support from the Gordon and Marilyn Macklin Foundation. She receives salary support for her role as the site Principal Investigator for research studies with Biohaven Pharmaceuticals and Pfizer and for serving on the Clinical Events Committee for a research study with Functional Neuromodulation. She also serves on the steering committees for the Parkinson Study Group's research study with both UCB and Bial Pharmaceuticals. Dr. Rosenthal also served on an advisory board for Reata pharmaceuticals and Biohaven Pharmaceuticals. Dr. Phillips: Dr. Phillips has no conflicts of interest to declare. Dr. Mari: Dr. Mari is a paid consultant for GB Sciences, AbbVie, and Ipsen. He is a speaker for AbbVie, Supernus, and Acadia. He holds shares in Sensory Cloud, NeuroReserve, GB Sciences, Neunos, D&D PharmaTech. He is a co-founder and CMO of Neuraly, Inc. and Z NeuroSciences, LLC.