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Review
. 2024 Sep;598(17):2074-2091.
doi: 10.1002/1873-3468.14995. Epub 2024 Aug 7.

Oxidative stress and aging: synergies for age related diseases

Daniela F Santos  1   2 , Sónia Simão  1   2   3 , Clévio Nóbrega  1   2   3   4 , José Bragança  1   2   3   4   5 , Pedro Castelo-Branco  1   2   3   4   5 , Inês M Araújo  1   2   3   4   5 ; ALFA Score Consortium
Affiliations
Free article
Review

Oxidative stress and aging: synergies for age related diseases

Daniela F Santos et al. FEBS Lett. 2024 Sep.
Free article

Abstract

Aging is characterized by a progressive decline in physiological function and underlies several disabilities, including the increased sensitivity of cells and tissues to undergo pathological oxidative stress. In recent years, efforts have been made to better understand the relationship between age and oxidative stress and further develop therapeutic strategies to minimize the impact of both events on age-related diseases. In this work, we review the impact of the oxidant and antioxidant systems during aging and disease development and discuss the crosstalk of oxidative stress and other aging processes, with a focus on studies conducted in elderly populations.

Keywords: healthy aging; oxidative modifications; oxidative stress.

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