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. 2025 Jan 1;110(1):206-211.
doi: 10.3324/haematol.2024.285416.

Contribution of copy number to improve risk stratification of adult T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials

Celia Gonzalez-Gil  1 , Mireia Morgades  2 , Thaysa Lopes  1 , Francisco Fuster-Tormo  1 , Pau Montesinos  3 , Pere Barba  4 , Marina Diaz-Beya  5 , Lourdes Hermosin  6 , Clara Maluquer  7 , Jose Gonzalez-Campos  8 , Teresa Bernal  9 , Marta Sitges Arriaga  10 , Lurdes Zamora  2 , Marta Pratcorona  11 , Rodrigo Martino  11 , Maria Jose Larrayoz  12 , Teresa Artola  13 , Anna Torrent  2 , Ferran Vall-Llovera  14 , Mar Tormo  15 , Cristina Gil  16 , Andres Novo  17 , Pilar Martinez-Sanchez  18 , Jordi Ribera  1 , Maria-Paz Queipo  19 , Teresa Gonzalez-Martinez  20 , Monica Cabrero  20 , Antonia Cladera  21 , Jose Cervera  3 , Alberto Orfao  22 , Josep Maria Ribera  23 , Eulalia Genesca  24
Affiliations

Contribution of copy number to improve risk stratification of adult T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials

Celia Gonzalez-Gil et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Genetic profile of adult T-cell acute lymphoblastic leukemia at diagnosis. (A) Mutational landscape of adult T-cell acute lymphoblastic leukemia (T-ALL) patients. Only alterations found in at least 5 patients are shown. Genes affected by both sum of single nucleotide variant (SNV)/insertions deletions (indel) and copy number variants (CNV) in the same patient are highlighted in brown. (B) Pairwise associations between altered genes identified in the same patient (left panel) and between genetic alterations and immunophenotype (right panel). Associations are shown only for alterations present in at least 10 patients. Combinations were tested using the Fisher test corrected by the Benjamini-Hochberg multiplicity test (considering significant co-existence when q<0.1). Positive correlations are represented by the blue range color and negative correlations by the red range color. (C) Box and whisker representation of cancer cell fractions (CCF) for CNV (left panel) and SNV/indel (right panel). The threshold to define clonality (0.5) is indicated by the dashed line. All statistical analyses were performed using SPSS version 24 (IBM Corp. Armonk, NY), GraphPad Prism® version 10 (GraphPad Software Inc., La Jolla, CA) and R version 4.1.0.
See this image and copyright information in PMC

References

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