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Review
. 2024 Jul 8;16(7):e64068.
doi: 10.7759/cureus.64068. eCollection 2024 Jul.

Enhancing Endometrial Health in Assisted Reproductive Technology (ART): Evaluating Autologous Endometrial Cells and Platelets-Rich Plasma (PRP) via Hysteroscopic Injections

Priti Karadbhajne  1 , Akash More  1 , Hellen Y Dzoagbe  2
Affiliations
Review

Enhancing Endometrial Health in Assisted Reproductive Technology (ART): Evaluating Autologous Endometrial Cells and Platelets-Rich Plasma (PRP) via Hysteroscopic Injections

Priti Karadbhajne et al. Cureus. .

Abstract

This review article examines the effectiveness of incorporating autologous endometrial cells and platelet-rich plasma (PRP) through hysteroscopic injections within the field of assisted reproductive technology (ART). This study assesses the outcomes of these injections on the susceptibility of the endometrium, the dynamics of the uterus, and the frequencies of pregnancy in individuals with refractory thin endometrium. Based on a complete examination of several trials, it becomes apparent that autologous PRP injections provide encouraging turnouts in augmenting endometrial thickness, raising endometrial receptivity, and, in the end, raising chances of being pregnant and successful delivery. The research highlights the promise of autologous PRP and minimally changed endometrial cellular treatments in enhancing outcomes in ART, especially for people who have had problems with implantation. This article gives a whole evaluation of the medical use of and upgrades regarding the utilization of infusions of PRP and autologous endometrial cells under hysteroscopic control to deal with infertility issues related to endometrial health through the synthesis of contemporary studies.

Keywords: biomarkers; endometrial receptivity; endometrial volumetric analysis; infertility therapy; instillations.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Assisted reproductive technologies for infertility
The author created this figure using the Canva platform.
Figure 2
Figure 2. MSCs propensity for multiple differentiation
MSCs: mesenchymal stem cells The author created this figure using the Canva platform.
Figure 3
Figure 3. Key processes mechanism of action for autologous cells
The author created this figure using the Canva platform.
Figure 4
Figure 4. The mechanisms of action of PRP in ART
ART: assisted reproductive technology; PRP: platelet-rich plasma The author created this figure using the Canva platform.
See this image and copyright information in PMC

References

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    1. Hysteroscopic injections of autologous endometrial cells and platelet-rich plasma in patients with thin endometrium: a pilot randomized study. Efendieva Z, Vishnyakova P, Apolikhina I, et al. Sci Rep. 2023;13:945. - PMC - PubMed

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