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. 2024 Jun 18;8(1):935-944.
doi: 10.3233/ADR-230101. eCollection 2024.

Relationship Between Excessive Daytime Sleepiness and Caudate Nucleus Volume in Patients with Subjective Cognitive Decline: A Study from the SILCODE Using the Volbrain

Ziqian Feng  1   2   3   4 , Jiayu Wang  1   2   4 , Lisi Xu  1   2 , Jiajing Wu  1   4 , Hongyi Li  1   2 , Ziqi Wang  1   2 , Mingjun Duan  1   2
Affiliations

Relationship Between Excessive Daytime Sleepiness and Caudate Nucleus Volume in Patients with Subjective Cognitive Decline: A Study from the SILCODE Using the Volbrain

Ziqian Feng et al. J Alzheimers Dis Rep. .

Abstract

Background: Excessive daytime sleepiness (EDS) and caudate nucleus volume alterations have been linked to Alzheimer's disease (AD), but their relationship remains unclear under the context of subjective cognitive decline (SCD).

Objective: This study aimed to investigate the relationship between EDS and caudate nucleus volume in patients with SCD.

Methods: The volume of entire brain was measured in 170 patients with SCD, including 37 patients with EDS and 133 non-EDS, from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Participants underwent a comprehensive assessment battery, including neuropsychological and clinical evaluations, blood tests, genetic analysis for APOE ɛ4, and structural MRI scans analyzed using the fully automated segmentation tool, volBrain.

Results: Patients with EDS had significantly increased volume in the total and left caudate nucleus compared to non-EDS. The most significant cognitive behavioral factor associated with caudate nucleus volume in the EDS was the Auditory Verbal Learning Test-recognition.

Conclusions: These findings suggest that EDS may be associated with alterations in caudate nucleus volume, particularly in the left hemisphere, in the context of SCD. Further research is necessary to understand the underlying mechanisms of this relationship and its implications for clinical management.

Keywords: Alzheimer’s disease; caudate nucleus; excessive daytime sleepiness; memory; subjective cognitive decline; volume.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Fig. 1
Fig. 1
Between-group difference in EDS and control with APOE ɛ4 carriers and non-carriers at total, right and left caudate nucleus volume.
Fig. 2
Fig. 2
Relationship between recognition recall score and left caudate nucleus volume in the EDS group. A) There is a significant negative correlation between recognition recall score and left caudate nucleus volume in the EDS. B) The significant negative correlation between recognition recall score and left caudate nucleus volume in the EDS with APOE ɛ4 non-carriers.
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