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. 2024 Aug 8;19(8):e0306928.
doi: 10.1371/journal.pone.0306928. eCollection 2024.

Health-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda

Charles Batte  1 , Andrew Weil Semulimi  1 , John Mukisa  2 , Mariam Nakabuye  1 , Jasper Nidoi  1 , David Mukunya  3 , Rosalind Parkes Ratanshi  4   5 , Barbara Castelnuovo  4 , Mohammed Lamorde  4 , David Meya  6 , William Checkley  7 , Robert Kalyesubula  8 , Trishul Siddharthan  9 , Joseph B Babigumira  10
Affiliations

Health-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda

Charles Batte et al. PLoS One. .

Abstract

Introduction: The presence of hypertension could reduce the health-related quality of life (HRQoL) of people with HIV (PWH). Yet, literature describing the HRQoL of PWH who have hypertension in Uganda is scarce making the design of locally adapted interventions cumbersome. In our study, we compared HRQoL scores of people with HIV with and without hypertension on long term antiretroviral therapy (ART) in Uganda.

Methods: We recruited 149 PWH with hypertension and 159 PWH without hypertension in the long-term ART cohort at an urban clinic in Kampala, Uganda. Data on socio-demographics were collected using an interviewer designed questionnaire while data on the World Health Organisation clinical stage viral load and CD4 count as well as ART duration were extracted from clinic electronic database and a generic EuroQol -5D- 5L (EQ-5D- 5L) and Medical Outcome Study (MOS-HIV) questionnaire used to collect HRQoL data. Data were summarized using descriptive statistics while inferential statistics were used to determine associations between key variables and HRQoL. Mann-Whitney U tests were used to compare HRQoL between groups of interest.

Results: One hundred ninety (61.7%) participants were female. PWH who had hypertension were older (Mean ± SD: 53.7 ± 8.3 vs 49.9 ± 8.6, p value <0.001) than those without hypertension. Participants with hypertension had lower overall median health utility scores (0.71 (0.33-0.80) vs 0.80 (0.44-0.80), p value = 0.029) and mean physical health score (48.44 ± 10.17 vs 51.44 ± 9.65, p value < 0.001) as opposed to those without hypertension. Hypertension (p value = 0.023), high income status, >70,000 UGX, (p value = 0.044), disclosure of the HIV status of the participants to their partner (p value = 0.026), and current history of smoking (p value = 0.029) were associated with low HRQoL scores.

Conclusion: Among people with HIV, those with hypertension had lower HRQoL compared to those without. This calls for inclusion of quality-of-life assessment in the management of PWH who have been diagnosed with hypertension to identify those at risk and plan early interventions.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The flow chart representing how participants were selected in this study.
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