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. 2025 Mar 17;231(3):746-750.
doi: 10.1093/infdis/jiae393.

The Emergent Invasive Serotype 4 ST10172 Strain Acquires vanG-Type Vancomycin-Resistance Element: A Case of a 66-Year-Old With Bacteremic Pneumococcal Pneumonia

Sopio Chochua  1 , Bernard Beall  2 , Wuling Lin  1 , Theresa Tran  1 , Joy Rivers  1 , Zhongya Li  3 , Melissa L Arvay  1 , Miwako Kobayashi  1 , Jessica Houston  4 , Sabra Arias  4 , Lesley McGee  1
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The Emergent Invasive Serotype 4 ST10172 Strain Acquires vanG-Type Vancomycin-Resistance Element: A Case of a 66-Year-Old With Bacteremic Pneumococcal Pneumonia

Sopio Chochua et al. J Infect Dis. .

Abstract

We report a single case of invasive pneumococcal disease (IPD) by serotype 4, multilocus sequence type 10172 (ST10172) isolate with vanG-type resistance genes and reduced vancomycin susceptibility. The isolate was recovered during 2022 from a 66-year-old resident with bacteremic pneumococcal pneumonia within a Centers for Disease Control and Prevention Active Bacterial Core surveillance (ABCs) site hospital. The patient had received 23-valent pneumococcal polysaccharide vaccine and there was no evidence of concurrent or prior receipt of vancomycin in the previous year. Serotype 4/ST10172 IPD has shown increases within western ABCs sites, and the recent acquisition of a vanG element warrants close monitoring of this lineage.

Keywords: Streptococcus pneumoniae; antibiotics; emergent lineages; invasive pneumococcal disease; vancomycin resistance.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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