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. 2025 Mar 4;194(3):608-624.
doi: 10.1093/aje/kwae264.

A data harmonization project of 3 large prospective cardiovascular health-focused cohorts

Matthew M Scarpaci  1 , Jee Won Park  2   3   4 , Laura Dionne  5 , Belinda L Needham  6 , Mario Sims  7 , Alka M Kanaya  8 , Namratha R Kandula  9 , Joseph L Fava  5   10 , Charles B Eaton  3   11   12 , Chanelle J Howe  2   3 , Akilah J Dulin  5
Affiliations

A data harmonization project of 3 large prospective cardiovascular health-focused cohorts

Matthew M Scarpaci et al. Am J Epidemiol. .

Abstract

Few prospective studies examine multilevel resilience resources and psychosocial factors in relation to cardiovascular health and disease. Recent research indicates that resilience resources are associated with a reduction in the incidence of cardiovascular disease-related events, but few studies have examined this relationship across different racial/ethnic populations or in large cohorts. Harmonization may address these limitations because it allows data from several cohorts to be analyzed together, potentially increasing sample size and in turn power overall and in minority populations. This article describes the process involved in combining 3 cardiovascular health-focused cohorts: Jackson Heart Study, Multi-Ethnic Study of Atherosclerosis, and Mediators of Atherosclerosis in South Asians Living in America Study. Using a systematic process, we identified appropriate data harmonization techniques to use in harmonizing variables across cohorts. Variables included exposures (eg, resilience resources), outcomes (eg, American Heart Association's Life's Simple 7), and covariates (eg, race and ethnicity). Post-harmonization examinations included psychometric analyses of the harmonized variables. A total of 13 284 participants were included in the final harmonized data set. This project provides opportunities for future research in resilience resources and informs future studies that need to harmonize data. Results based on the harmonized data set could inform interventions and policies.

Keywords: cardiovascular disease; data harmonization; data pooling; psychosocial risks; resilience.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Data harmonization process.
See this image and copyright information in PMC

References

    1. Ahmad FB, Cisewski JA, Minino A, et al. Provisional mortality data - United States, 2020. MMWR Morb Mortal Wkly Rep. 2021;70(14):519-522. 10.15585/mmwr.mm7014e1 - DOI - PMC - PubMed
    1. CDC . Health, United States Spotlight: Racial and Ethnic Disparities in Heart Disease. https://www.cdc.gov/nchs/hus/spotlight/HeartDiseaseSpotlight_2019_0404.pdf
    1. Rodriguez F, Hastings KG, Boothroyd DB, et al. Disaggregation of cause-specific cardiovascular disease mortality among Hispanic subgroups. JAMA Cardiol. 2017;2(3):240-247. 10.1001/jamacardio.2016.4653 - DOI - PMC - PubMed
    1. Husaini BA, Levine RS, Norris KC, et al. Heart failure hospitalization by race/ethnicity, gender and age in California: implications for prevention. Ethn Dis. 2016;26(3):345-354. 10.18865/ed.26.3.345 - DOI - PMC - PubMed
    1. Shah NS, Palaniappan LP, Khan SS. Proportional mortality from ischemic heart disease among Asian American subgroups, from 2018 to 2020. JAMA Intern Med. 2022;182(10):1101-1103. 10.1001/jamainternmed.2022.3616 - DOI - PMC - PubMed

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