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Review
. 2024 May 3;19(5):257-278.
doi: 10.1080/17460751.2024.2343555. Epub 2024 May 22.

Bioactive ceramic-based materials: beneficial properties and potential applications in dental repair and regeneration

Jiale Wang  1 , Linglin Zhang  1 , Kun Wang  1
Affiliations
Review

Bioactive ceramic-based materials: beneficial properties and potential applications in dental repair and regeneration

Jiale Wang et al. Regen Med. .

Abstract

Bioactive ceramics, primarily consisting of bioactive glasses, glass-ceramics, calcium orthophosphate ceramics, calcium silicate ceramics and calcium carbonate ceramics, have received great attention in the past decades given their biocompatible nature and excellent bioactivity in stimulating cell proliferation, differentiation and tissue regeneration. Recent studies have tried to combine bioactive ceramics with bioactive ions, polymers, bioactive proteins and other chemicals to improve their mechanical and biological properties, thus rendering them more valid in tissue engineering scaffolds. This review presents the beneficial properties and potential applications of bioactive ceramic-based materials in dentistry, particularly in the repair and regeneration of dental hard tissue, pulp-dentin complex, periodontal tissue and bone tissue. Moreover, greater insights into the mechanisms of bioactive ceramics and the development of ceramic-based materials are provided.

Keywords: bioactive ceramics; bone formation; dental hard tissue; periodontal regeneration; pulp–dentin complex regeneration.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

Figures

Figure 1.
Figure 1.
The role of bioactive ceramics-based materials in dental repair and regeneration.
Figure 2.
Figure 2.
The role of bioactive ceramics-based materials in remineralization and regeneration of dental hard tissues.
Figure 3.
Figure 3.
The role of bioactive ceramics-based materials in pulp-dentin complex regeneration.
Figure 4.
Figure 4.
The role of bioactive ceramics-based materials in periodontal regeneration.
Figure 5.
Figure 5.
The role of bioactive ceramics-based materials in bone formation.
See this image and copyright information in PMC

References

    1. Jafari N, Habashi MS, Hashemi A, Shirazi R, Tanideh N, Tamadon A. Application of bioactive glasses in various dental fields. Biomater Res. 2022;26(1):31. doi:10.1186/s40824-022-00274-6 - DOI - PMC - PubMed
    1. Pina S, Rebelo R, Correlo VM, Oliveira JM, Reis RL. Bioceramics for osteochondral tissue engineering and regeneration. Adv Exp Med Biol. 2018;1058:53–75. doi:10.1007/978-3-319-76711-6_3 - DOI - PubMed
    1. Coaguila-Llerena H, Ochoa-Rodriguez VM, Castro-Núñez GM, Faria G, Guerreiro-Tanomaru JM, Tanomaru-Filho M. Physicochemical properties of a bioceramic repair material – BioMTA. Braz Dent J. 2020;31(5):511–515. doi:10.1590/0103-6440202003163 - DOI - PubMed
    1. van Rijt S, de Groot K, Leeuwenburgh SCG. Calcium phosphate and silicate-based nanoparticles: history and emerging trends. Tissue Eng Part A. 2022;28(11–12):461–477. doi:10.1089/ten.TEA.2021.0218 - DOI - PubMed
    1. Zhou Q, Su X, Wu J, et al. . Additive manufacturing of bioceramic implants for restoration bone engineering: technologies, advances, and future perspectives. ACS Biomater Sci Eng. 2023;9(3):1164–1189. doi:10.1021/acsbiomaterials.2c01164 - DOI - PubMed

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