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Review
. 2024 Jun 24;86(8):4705-4713.
doi: 10.1097/MS9.0000000000002258. eCollection 2024 Aug.

Prevalence of mental health disorders in knee osteoarthritis patients: a systematic review and meta-analysis

Borja Merry Del Val  1 , Saurin R Shukla  2 , Malik O Oduoye  3 , Mugisha Nsengiyumva  4 , Tadele Tesfaye  5 , Wojciech M Glinkowski  6   7
Affiliations
Review

Prevalence of mental health disorders in knee osteoarthritis patients: a systematic review and meta-analysis

Borja Merry Del Val et al. Ann Med Surg (Lond). .

Abstract

Background: Knee osteoarthritis (OA) is a prevalent degenerative disease affecting synovial joints, predominantly the knee, leading to various complications, including mental health conditions like depression and anxiety. This systematic review aimed to determine the prevalence of depression and anxiety in knee OA patients.

Methods: A comprehensive literature search was conducted in various databases till September 15, 2023. Studies focusing on the prevalence of mental health issues in patients with knee OA were included, excluding narrative reviews, protocols, unpublished reports, editorials, case reports, abstracts, and commentaries. All statistical analyses were performed in R version 4.2.3.

Results: This review included a total of 14 studies involving middle-aged to elderly adult patients with knee OA, with ages ranging from 45 to 75 years. Among these, 13 studies involving 3390 adult patients with an average age of 59.75 years reported a pooled prevalence of depression of 30% (95% confidence interval: 18-43), demonstrating a substantial heterogeneity (I 2=98%). Additionally, anxiety was identified with a combined prevalence of 27% (95% confidence interval: 24-30) based on three studies that included 1407 older adult patients with an average age of 62.1 years. These studies displayed minimal heterogeneity (I 2=7%).

Conclusion: The findings show a significant prevalence of depression among adult patients with knee OA and anxiety among older adults with knee OA, emphasizing the need for integrated healthcare approaches that address both orthopedic and mental health conditions. More comprehensive research is essential to deepen our understanding of the connection between mental illnesses and knee OA and to develop effective preventive and treatment strategies.

Keywords: anxiety; depression; osteoarthritis; prevalence; systematic review.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram depicting the screening and selection process. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Figure 2
Figure 2
Forest plot illustrating the pooled prevalence of depression.
Figure 3
Figure 3
Forest plot illustrating the prevalence results of anxiety.
Figure 4
Figure 4
Forest plot depicting the results of subgroup analysis for the scale used to measure depression.
Figure 5
Figure 5
Results of depression subgroup analysis based on study design.
See this image and copyright information in PMC

References

    1. Sen R, Hurley JA. Osteoarthritis Treasure Island: Stat Pearls; 2022.
    1. Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet 2005;365:965–973. - PubMed
    1. Hurley MV, Mitchell HL, Walsh N. In osteoarthritis, the psychosocial benefits of exercise are as important as physiological improvements. Exerc Sports Sci Rev 2003;31:138–143. - PubMed
    1. Park H-J, Lee S-K. The association between osteoarthritis and health-related quality of life in women aged 50 years and over using the Korea National Health and Nutrition Examination Survey (KNHANES) data. Korean J Health Educ Promot 2012;29:23–32.
    1. Jung JH, Seok H, Kim JH, et al. . Association between osteoarthritis and mental health in a Korean population: a nationwide study. Int J Rheum Dis 2018;21:611–619. - PubMed

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