beta-Lactamases and beta-lactam resistance in Escherichia coli
- PMID: 3911882
- PMCID: PMC176364
- DOI: 10.1128/AAC.28.5.703
beta-Lactamases and beta-lactam resistance in Escherichia coli
Abstract
Escherichia coli strains determining 17 different plasmid-determined beta-lactamases were tested for resistance to new broad-spectrum beta-lactam antibiotics. Several beta-lactamases demonstrated enhanced resistance to cefamandole but only low-level resistance to other agents. High production of cloned E. coli chromosomal beta-lactamase, however, provided resistance to cefamandole, cefoxitin, cefotaxime, ceftazidime, and aztreonam but not to BMY-28142 or imipenem.
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