COSMIC-312, a disappointing result-is that so surprising?
- PMID: 39118945
- PMCID: PMC11304426
- DOI: 10.21037/atm-23-421
COSMIC-312, a disappointing result-is that so surprising?
Keywords: Hepatocellular carcinoma (HCC); gene expression; immune checkpoint inhibitor (ICI); tyrosine kinase inhibitor (TKI).
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-23-421/coif). X.A. reports consulting fees received from Bayer, payments or honoraria from Servier, Ipsen, EISAI, and Bayer to institution, support for attending meetings and/or travel from Ipsen, Milan, Gilead. M.B. reports consulting fees received from Merck-Schering Plow, Gilead, Janssen, Roche, Abbvie and BMS, payments or honoraria from Vertex Boehringer-Ingelheim and GSK, and support for attending meetings and/or travel from Gilead, Roche, Abbvie and BMS. R.A. reports consulting fees received from Bayer, Ipsen, Eisai, Abbvie, MSD, Intercept, payments or honoraria from Gilead, Bayer, Abbvie, and support for attending meetings and/or travel from Gilead and Abbvie. The authors have no other conflicts of interest to declare.
Comment on
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Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312): a multicentre, open-label, randomised, phase 3 trial.Lancet Oncol. 2022 Aug;23(8):995-1008. doi: 10.1016/S1470-2045(22)00326-6. Epub 2022 Jul 4. Lancet Oncol. 2022. PMID: 35798016 Clinical Trial.
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