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Case Reports
. 2024 Jul 9;16(7):e64182.
doi: 10.7759/cureus.64182. eCollection 2024 Jul.

A Rare Case of Metastatic Adrenal Melanoma

Rohma R Khan  1 , Sunny Kahlon  1 , Jason-Paul Maragh  1 , Alyssa Kimble  1 , Shanu Gupta  1
Affiliations
Case Reports

A Rare Case of Metastatic Adrenal Melanoma

Rohma R Khan et al. Cureus. .

Abstract

Metastatic melanoma presents a significant clinical challenge, characterized by its aggressive nature and propensity to spread to multiple organ systems. Despite advances in detection and treatment, managing metastatic disease remains complex. Here, we present the case of a 43-year-old male with metastatic melanoma displaying an unusual pattern of involvement, affecting the adrenal gland, liver, spleen, and bones. The diagnostic process was intricate, involving atypical hormonal profiles and a negative BRAF status, necessitating a comprehensive approach for accurate characterization and treatment selection. Immunotherapy demonstrated efficacy but also highlighted the emergence of immune-related adverse events, notably hyperglycemia. This case discusses the heterogeneous nature of metastatic melanoma and underscores the importance of a multidisciplinary approach, close monitoring, and consideration of evolving treatment strategies in its management.

Keywords: adrenal melanoma; adult hospital medicine; combined nivolumab and ipilimumab therapy; flank pain; immunotherapy-related adverse events; large adrenal mass; metastatic melanoma treatment; metastatic skin cancer; multidisciplinary tumor board; pheochromocytoma differential.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. MRI image of the left adrenal mass
MRI: Magnetic resonance imaging
See this image and copyright information in PMC

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