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Case Reports
. 2024 Jul 9;16(7):e64163.
doi: 10.7759/cureus.64163. eCollection 2024 Jul.

Familial Spontaneous Keloids: Examining Thoracic Manifestations in Two Brothers

Ioannis Kyriazidis  1 , Efterpi Demiri  2   1 , Pericles Foroglou  2   1
Affiliations
Case Reports

Familial Spontaneous Keloids: Examining Thoracic Manifestations in Two Brothers

Ioannis Kyriazidis et al. Cureus. .

Abstract

Keloids are complex fibroproliferative disorders with diverse clinical presentations. Spontaneous keloids (SKs) represent a rare subtype that emerges without any known preceding traumatic event. This report presents a case of familial spontaneous keloids appearing on the thoracic region in two brothers with no prior history of trauma or keloid occurrence in other family members. The lesions exhibited progressive growth over several years but responded to cycles of triamcinolone treatment. This case underscores an unusual spontaneous occurrence of keloids in the thoracic region of two siblings, highlighting the potential genetic predisposition in the aetiology of these lesions. Additionally, this instance reinforces the concept that keloids can develop spontaneously without any apparent trauma in the affected area.

Keywords: familial keloid; familial spontaneous keloids; genetic predisposition; keloid formation; keloid pathogenesis; keloids; siblings; spontaneous keloid; thoracic region.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Clinical presentation of spontaneous keloids on the sternal region of a 41-year-old male patient
The images depict the keloid lesions from multiple angles, illustrating their size, shape, and distribution. The keloids developed without any preceding trauma or identifiable aggravating factors, suggesting a potential genetic predisposition.
Figure 2
Figure 2. Pedigree chart depicting familial keloid manifestation in our patient's family
Figure 3
Figure 3. Multiple keloid scars on the chest of the patient's youngest brother
The lesions developed spontaneously without any preceding trauma, further supporting the hypothesis of a genetic predisposition to keloid formation within this family.
See this image and copyright information in PMC

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