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. 2024 Aug 20;13(16):e035168.
doi: 10.1161/JAHA.124.035168. Epub 2024 Aug 9.

Cardiovascular Risks in People With Narcolepsy: Expert Panel Consensus Recommendations

Younghoon Kwon  1 , Apoor S Gami  2 , Shahrokh Javaheri  3 , Gregg S Pressman  4 , Thomas E Scammell  5 , Lee A Surkin  6 , Phyllis C Zee  7
Affiliations

Cardiovascular Risks in People With Narcolepsy: Expert Panel Consensus Recommendations

Younghoon Kwon et al. J Am Heart Assoc. .

Abstract

Background: Observational and retrospective studies suggest that people with narcolepsy may have an increased prevalence of cardiovascular and cardiometabolic comorbidities and may be at greater risk for future cardiovascular events. An expert consensus panel was formed to establish agreement on the risk of hypertension and cardiovascular/cardiometabolic disease in people with narcolepsy and to develop strategies to mitigate these risks.

Methods and results: Experts in sleep medicine and cardiology were selected to participate in the panel. After reviewing the relevant literature, the experts identified key elements, drafted recommendation statements, and developed discussion points to provide supporting evidence for the recommendations. The draft and final recommendations were rated on a scale from 0 (not at all agree) to 4 (very much agree). All experts had an agreement rating of 4.0 for all 14 revised recommendation statements for patients with narcolepsy. These statements comprised 3 themes: (1) recognize the risk of hypertension and cardiovascular/cardiometabolic disease, (2) reduce the risk of hypertension and cardiovascular/cardiometabolic disease, and (3) reduce sodium intake to lower the risk of hypertension and cardiovascular disease.

Conclusions: These consensus recommendations are intended to increase awareness of potential cardiovascular/cardiometabolic risks in patients with narcolepsy for all clinicians. Early monitoring for, and prevention of, cardiovascular risks in this population are of great importance, especially as narcolepsy usually develops in adolescents and young adults, who will be exposed to adverse effects of the disease for decades. Prospective systematic studies are needed to determine association and causation of narcolepsy with cardiovascular/cardiometabolic disorders.

Keywords: heart disease; hypertension; narcolepsy; sleep; sodium.

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Figures

Figure 1
Figure 1
Overview of narcolepsy characteristics/symptoms (A) and potential cardiovascular/cardiometabolic risk factors associated with narcolepsy and narcolepsy treatments (B).
Figure 2
Figure 2
Flowchart of consensus panel process.
See this image and copyright information in PMC

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