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. 2024 Jul 31;14(15):2231.
doi: 10.3390/ani14152231.

Use of Bedinvetmab (Librela®) for Canine Osteoarthritis in France, Germany, Italy, Spain, and the UK: Quantitative Analysis of Veterinarian Satisfaction and Real-World Treatment Patterns

Edwina Gildea  1 , Cyndy North  2 , Kate Walker  2 , Francis Adriaens  2 , Benedict Duncan X Lascelles  3
Affiliations

Use of Bedinvetmab (Librela®) for Canine Osteoarthritis in France, Germany, Italy, Spain, and the UK: Quantitative Analysis of Veterinarian Satisfaction and Real-World Treatment Patterns

Edwina Gildea et al. Animals (Basel). .

Abstract

Bedinvetmab (Librela®) represents a new class of canine osteoarthritis pain therapy. The aim of this study was to understand patient selection, usage behaviours, and satisfaction amongst veterinarians using bedinvetmab. Overall, 1932 patient record forms (PRF) were collected from 375 veterinarians across five countries in Europe. Veterinarians were asked to provide 5-7 PRF representing an average patient prescribed bedinvetmab. Veterinarian satisfaction with bedinvetmab usage averaged 8.0 out of 10.0 across all countries. Dissatisfaction as a reason for discontinuation was less than 1% for veterinarians. Veterinarians prescribed bedinvetmab broadly, across patient severity stages, weights, and ages. Adherence to monthly dosing per the product label was over 99%, and compliance with bedinvetmab treatment regimens was 85%. Following initiation of bedinvetmab, the proportion of patients requiring multiple pharmacological therapies for osteoarthritis pain fell from 47% to 31% (p < 0.05). After initiation of bedinvetmab, the mean total number of pharmacological therapies per patient across the population was 1.3, a reduction from 1.9 pre-treatment (p < 0.05). This investigation provides evidence on the benefit of bedinvetmab use post-launch in a broad population of dogs across the five most populous countries in western Europe. Compliance and satisfaction appear high and the use of other analgesic therapies to treat osteoarthritis pain is reduced in most cases following administration of bedinvetmab.

Keywords: Librela; bedinvetmab; canine degenerative joint disease; canine osteoarthritis; pain; real-world.

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Conflict of interest statement

The authors whose names are listed immediately below report the following details of affiliation or involvement in an organisation or entity with a financial or non-financial interest in the subject matter or materials discussed in this manuscript: Edwina Gildea, Cyndy North, Kate Walker, and Francis Adriaens were employed by Zoetis over the period of this study. BDX Lascelles is a paid consultant for Zoetis.

Figures

Figure 1
Figure 1
Flow of study activities represented in chronological order: prescribing and recruitment, record form completion and submission, and patient-level data analysis.
Figure 2
Figure 2
Compliance with bedinvetmab therapy across countries. Compliance is defined as the total percentage of patients who abided with product label dosages. From left to right the compliance percentages included are the total (EU5) percentage and individual percentages reported in each country (France, Germany, Italy, Spain, UK).
See this image and copyright information in PMC

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