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Review
. 2024 Jul 24;29(15):3461.
doi: 10.3390/molecules29153461.

Long Non-Coding RNA AGAP2-AS1: A Comprehensive Overview on Its Biological Functions and Clinical Significances in Human Cancers

Feng Ma  1 , Bingbing Zhang  1 , Yiqi Wang  1 , Chenghua Lou  1
Affiliations
Review

Long Non-Coding RNA AGAP2-AS1: A Comprehensive Overview on Its Biological Functions and Clinical Significances in Human Cancers

Feng Ma et al. Molecules. .

Abstract

Long non-coding RNAs (lncRNAs) are well known for their oncogenic or anti-oncogenic roles in cancer development. AGAP2-AS1, a new lncRNA, has been extensively demonstrated as an oncogenic lncRNA in various cancers. Abundant experimental results have proved the aberrantly high level of AGAP2-AS1 in a great number of malignancies, such as glioma, colorectal, lung, ovarian, prostate, breast, cholangiocarcinoma, bladder, colon and pancreatic cancers. Importantly, the biological functions of AGAP2-AS1 have been extensively demonstrated. It could promote the proliferation, migration and invasion of cancer cells. Simultaneously, the clinical significances of AGAP2-AS1 were also illustrated. AGAP2-AS1 was exceptionally overexpressed in various cancer tissues. Clinical studies disclosed that the abnormal overexpression of AGAP2-AS1 was tightly connected with overall survival (OS), lymph nodes metastasis (LNM), clinical stage, tumor infiltration, high histological grade (HG), serous subtype and PFI times. However, to date, the biological actions and clinical significances of AGAP2-AS1 have not been systematically reviewed in human cancers. In the present review, the authors overviewed the biological actions, potential mechanisms and clinical features of AGAP2-AS1 according to the previous studies. In summary, AGAP2-AS1, as a vital oncogenic gene, is a promising biomarker and potential target for carcinoma prognosis and therapy.

Keywords: AGAP2-AS1; biological function; clinicopathological character; mechanism; oncogene.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Related information of AGAP2-AS1. (A) The genomic localization of AGAP2-AS1 (https://www.ncbi.nlm.nih.gov, accessed on 6 July 2024). (B) Secondary structure of AGAP2-AS1. (C) Three-dimensional structure of AGAP2-AS1. (D) Motif analysis of AGAP2-AS1. (E) The expression level of AGAP2-AS1 in clinical carcinomatous (red color) and non-carcinomatous (blue color) tissues was analyzed using the UALCAN database (https://ualcan.path.uab.edu/, accessed on 18 May 2024). BLCA: Bladder urothelial carcinoma; BRCA: Breast invasive carcinoma; CESC: Cervical squamous cell carcinoma; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; ESCA: Esophageal carcinoma; GBM: Glioblastoma multiforme; HNSC: Head and neck squamous cell carcinoma; KICH: Kidney chromophobe; KIRC: Kidney renal clear cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; PAAD: Pancreatic adenocarcinoma; PCPG: Pheochromocytoma and paraganglioma; PRAD: Prostate adenocarcinoma; READ: Rectum adenocarcinoma; SARC: Sarcoma; THYM: Thymoma; THCA: Thyroid carcinoma; UCEC: Uterine corpus endometrial carcinoma.
Figure 2
Figure 2
The potential molecular mechanisms of AGAP2-AS1 in human carcinomas. AGAP2-AS1 promoted cancer proliferation, migration and invasion in various cancers, including glioma, PTC, LC, melanoma, ccRCC, GC, PC, EC, BC, CRC and CLC.
Figure 3
Figure 3
The AGAP2-AS1 expression profile, and its correlation with cancer stage, tumor histology and survival analyzed using the UALCAN database (https://ualcan.path.uab.edu/, accessed on 20 May 2024).
Figure 4
Figure 4
The AGAP2-AS1 expression in normal, tumor, and metastatic tumor tissues using the TNM plot (https://tnmplot.com/analysis/, accessed on 22 May 2024).
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