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Multicenter Study
. 2024 Jul 31;16(15):2487.
doi: 10.3390/nu16152487.

Outcomes of Bariatric Surgery in Patients with Schizophrenia

Inka Miñambres  1   2   3 , Miguel Ángel Rubio-Herrera  4   5 , Joana Nicolau  6 , Camila Milad  7 , Maria José Morales  8 , Marta Bueno  9   10 , Alfonso Calañas  11 , Mar Carceller-Sindreu  12   13   14 , Ana de Hollanda  7   15 ; Obesity Area of the Spanish Society of Endocrinology and Nutrition (ObesitySEEN)
Affiliations
Multicenter Study

Outcomes of Bariatric Surgery in Patients with Schizophrenia

Inka Miñambres et al. Nutrients. .

Abstract

Background: Outcomes of bariatric surgery (BS) in patients with schizophrenia are poorly understood. We aimed to analyze the effects of BS in patients with schizophrenia (SZ) or schizoaffective disorder (SZA).

Methods: This was a multicenter, retrospective case-control study in patients with SZ or SZA who had undergone BS in seven public referral hospitals in Spain. Controls without psychiatric comorbidity were selected in a 1:4 ratio. Detailed clinical and biochemical data were collected preoperatively and at 12, 24, 36, 48, and 60 months after BS.

Results: Twenty patients with SZ (n = 15; 75%) or SZA (n = 5; 25%) and 80 matched controls were studied. There were no differences between patients and controls concerning the evolution of the percentage of total weight loss. The remission rate of the main comorbidities was similar between groups except for hypertension, which was lower in patients with a psychotic disorder from year 3. There were no mortalities within 30 days of surgery in either group. The psychiatric medication burden did not change during follow-up.

Conclusions: BS is safe and effective in carefully selected patients with SZ. The course of the psychiatric disease does not seem to be worsened by the procedure.

Keywords: obesity; obesity surgery; schizophrenia; severe mental illness; weight loss.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Remission of main obesity comorbidities at 1 (A), 3 (B), and 5 years (C) after bariatric surgery in patients with schizophrenia and controls (T2DM: type 2 diabetes; OSAS: obstructive sleep apnea syndrome).
Figure 2
Figure 2
Evolution of the medication load of patients with schizophrenia before and after bariatric surgery (formula at Hanlon et al. 2009 [20]).
See this image and copyright information in PMC

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