The Role of Nutrition on Thyroid Function

Abstract

Thyroid function is closely linked to nutrition through the diet-gut-thyroid axis. This narrative review highlights the influence of nutritional components and micronutrients on thyroid development and function, as well as on the gut microbiota. Micronutrients such as iodine, selenium, iron, zinc, copper, magnesium, vitamin A, and vitamin B12 influence thyroid hormone synthesis and regulation throughout life. Dietary changes can alter the gut microbiota, leading not just to dysbiosis and micronutrient deficiency but also to changes in thyroid function through immunological regulation, nutrient absorption, and epigenetic changes. Nutritional imbalance can lead to thyroid dysfunction and/or disorders, such as hypothyroidism and hyperthyroidism, and possibly contribute to autoimmune thyroid diseases and thyroid cancer, yet controversial issues. Understanding these relationships is important to rationalize a balanced diet rich in essential micronutrients for maintaining thyroid health and preventing thyroid-related diseases. The synthetic comprehensive overview of current knowledge shows the importance of micronutrients and gut microbiota for thyroid function and uncovers potential gaps that require further investigation.

Keywords: gut-thyroid axis; microbiome; micronutrients; thyroid; thyroid hormones; trace elements; vitamins.

Figure 1

The overall effects of known nutrients and micronutrients on thyroid function. NIS: Na⁺ −Iodid Symporter (iodide uptake); DUOX: dual oxidase (H₂O₂ generation); TPO: thyroperoxidase (hemoprotein); TG: thyroglobulin (synthesis and storage protein); GPX: glutathione peroxidase (antioxidant defense); thyroid hormones (TH); monoiodotyrosine (MIT) and diiodotyrosine (DIT); D1, 2, 3: deiodinase (TH in−/activation). Created with BioRender.com, accessed on 19 April 2024.