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. 2024 Aug 2;14(15):1675.
doi: 10.3390/diagnostics14151675.

Association of Sleep Patterns and Respiratory Disturbance Index with Physiological Parameters in Pediatric Patients with Self-Perceived Short Stature

Jing-Yang Huang  1   2 , Pei-Lun Liao  1   2 , Hua-Pin Chang  3 , Pen-Hua Su  4   5
Affiliations

Association of Sleep Patterns and Respiratory Disturbance Index with Physiological Parameters in Pediatric Patients with Self-Perceived Short Stature

Jing-Yang Huang et al. Diagnostics (Basel). .

Abstract

Objective: To investigate the relationships of sleep patterns and respiratory disturbance index (RDI) with key physiological parameters (height, body mass index (BMI), bone age (BA), and IGF-1 levels) in children aged 6 to 16 years with self-perceived short stature.

Methods: For this cross-sectional study, conducted from October 2019 to November 2021, 238 children aged 6 to 16 years with self-perceived short stature were enrolled. The primary outcomes of sleep patterns and the RDI were non-invasively collected at home using the LARGAN Health AI-Tech Sleep Apnea and Sleep Quality Examination System, which operates based on polygraphy. Additionally, various physiological parameters, including height, BMI, bone age, and IGF-1 levels, were measured to assess their associations with sleep patterns and RDI.

Results: Significant age-related reductions were observed in both the total and deep sleep durations. Children aged 6-9 years averaged 8.5 ± 1.0 h of total sleep, which decreased to 8.1 ± 1.1 h in ages 10-11 and further to 7.5 ± 0.9 h in ages 12-16 (p < 0.0001). Deep sleep followed a similar pattern, decreasing from 4.4 ± 1.1 h in the youngest group to 3.3 ± 1.0 h in the oldest (p < 0.0001). Notably, girls experienced significantly longer deep sleep than boys, averaging 4.0 ± 1.2 h compared to 3.6 ± 1.2 h (p = 0.0153). In a multivariable regression analysis, age (beta = 4.89, p < 0.0001) and RDI (beta = -0.54, p = 0.0022) were significantly associated with body height. Age and deep sleep duration (beta = -0.02, p = 0.0371) were significantly associated with BMI.

Conclusions: The results demonstrate significant age-related decreases in the total and deep sleep duration among children with self-perceived short stature, along with a notable association between RDI and body height and an association between deep sleep duration and BMI. These findings suggest that sleep disturbances in pediatric endocrine patients are intricately linked with physiological growth parameters. The identified correlations underline the importance of monitoring sleep patterns in this demographic to better understand the impact of endocrine disorders on developmental health. Further research is needed to explore interventions that could alleviate these sleep disturbances, thereby potentially improving outcomes for the affected children.

Keywords: children; home portable sleep detection device; precocious puberty; sleep.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The distribution of sleep patterns and RDI by body sex and age. REM, rapid eye movement; RDI, respiratory disturbance index. (A) Total sleep duration (hours). (B) Light sleep duration (hours). (C) Deep sleep duration (hours). (D) Rapid eye movement duration (hours). (E) Respiratory disturbance index.
Figure 1
Figure 1
The distribution of sleep patterns and RDI by body sex and age. REM, rapid eye movement; RDI, respiratory disturbance index. (A) Total sleep duration (hours). (B) Light sleep duration (hours). (C) Deep sleep duration (hours). (D) Rapid eye movement duration (hours). (E) Respiratory disturbance index.
Figure 2
Figure 2
Distribution of sleep patterns and RDI according to body height and age. REM, rapid eye movement; RDI, respiratory disturbance index. (A) Total sleep duration (hours). (B) Light sleep duration (hours). (C) Deep sleep duration (hours). (D) Rapid eye movement duration (hours). (E) Respiratory disturbance index.
Figure 2
Figure 2
Distribution of sleep patterns and RDI according to body height and age. REM, rapid eye movement; RDI, respiratory disturbance index. (A) Total sleep duration (hours). (B) Light sleep duration (hours). (C) Deep sleep duration (hours). (D) Rapid eye movement duration (hours). (E) Respiratory disturbance index.
Figure 3
Figure 3
Distribution of sleep patterns and RDI according to BMI and age. REM, rapid eye movement; RDI, respiratory disturbance index; BMI, body mass index. (A) Total sleep duration (hours). (B) Light sleep duration (hours). (C) Deep sleep duration (hours). (D) Rapid eye movement duration (hours). (E) Respiratory disturbance index.
Figure 3
Figure 3
Distribution of sleep patterns and RDI according to BMI and age. REM, rapid eye movement; RDI, respiratory disturbance index; BMI, body mass index. (A) Total sleep duration (hours). (B) Light sleep duration (hours). (C) Deep sleep duration (hours). (D) Rapid eye movement duration (hours). (E) Respiratory disturbance index.
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