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Review
. 2024 Jul 27;25(15):8224.
doi: 10.3390/ijms25158224.

Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness

Kar Wai Alvin Lee  1 , Kwin Wah Lisa Chan  1 , Angela Lee  2 , Cheuk Hung Lee  1 , Jovian Wan  3 , Sky Wong  4 , Kyu-Ho Yi  5   6
Affiliations
Review

Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness

Kar Wai Alvin Lee et al. Int J Mol Sci. .

Abstract

Polynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration. This review aims to provide an overview of the current practices and perceived effectiveness of polynucleotides in aesthetic medicine. A comprehensive search of the literature was conducted using keywords related to polynucleotides, cosmetic application, and aesthetic application. Studies were selected based on their relevance to aesthetic medicine and the inclusion of human subjects. The review found that polynucleotides have been used to improve skin texture, reduce wrinkle depth, and enhance facial appearance. The studies reported varying degrees of efficacy and safety, with some studies demonstrating significant improvements in skin elasticity and hydration. However, others reported limited or no benefits. The review also highlighted the need for further research to establish the optimal use and efficacy of polynucleotides in aesthetic medicine. While the existing literature suggests that polynucleotides may have potential benefits in aesthetic medicine, more research is needed to fully understand their mechanisms of action and optimal use. Clinicians should be aware of the current limitations and potential risks associated with the use of polynucleotides in aesthetic medicine.

Keywords: aesthetic medicine; cosmetic medicine; facial appearance; polynucleotides; skin texture; wrinkle depth.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The higher concentration of DNA particles enhances environmental conditions, leading to increased cellular proliferation and regeneration. The more stressful environmental conditions, the less cellular proliferation there would be.
Figure 2
Figure 2
Polydeoxynucleotide (PDRN) has been used in two ways: adenosine A2A receptor stimulation and salvage pathway. And in many cases, we explain the polynucleotide in the same pathway, but no research has yet revealed the mechanism. The image depicts two pathways: A2 receptor stimulation, which activates a cascade leading to angiogenesis via VEGF and angiopoietin, and the salvage pathway, which recycles nucleotides for DNA synthesis by breaking down and reusing purine and pyrimidine bases.
Figure 3
Figure 3
Polydeoxyribonucleotide (PDRN) products are now utilized for aesthetic purposes. The image above shows a pre-syringed PDRN product named PLYE (Sihler Inc., Seoul, Republic of Korea), while the image below features a vial type of PDRN called Eruajae (Hyundae Meditech Co., Wonju, Republic of Korea).
Figure 4
Figure 4
PN has increasingly gained prominence in aesthetics and cosmetic applications. Numerous PN products are available in the market for aesthetic purposes, with notable examples including Rejuran (Pharmaresearch Inc., Gangneung-si, Republic of Korea) and Doshaine PN (Hyundae Meditech Co., Wonju, Republic of Korea), both of which are offered in prefilled syringes.
See this image and copyright information in PMC

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