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. 2024 Jul;177(3):313-317.
doi: 10.1007/s10517-024-06180-2. Epub 2024 Aug 10.

Effect of Hafnia alvei on Morphophysiologic Parameters and Gut Microbiota of Mice with Inherited Type 2 Diabetes Mellitus

V A Zolotarev  1 , V O Murovets  2 , N S Novikova  3 , E I Ermolenko  3 , A L Sepp  2 , R P Khropycheva  2
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Effect of Hafnia alvei on Morphophysiologic Parameters and Gut Microbiota of Mice with Inherited Type 2 Diabetes Mellitus

V A Zolotarev et al. Bull Exp Biol Med. 2024 Jul.

Abstract

Inbred mouse strains KK.Cg-a/a and KK.Cg-Ay/a known as genetic models of type 2 diabetes mellitus significantly surpassed the control strain C57BL/6J in the body weight, relative weight of extractable fat, and basal blood glucose levels. Real-timePCR of fecal samples from KK.Cg-a/a and KK.Cg-Ay/a mice revealed dysbiosis typical of type 2 diabetes mellitus in humans and animals. Long-term intragastric administration of a suspension of Hafnia alvei bacteria had no effect on the above morphometric and biochemical parameters. At the same time, recovery of the Bacteroides spp. population in KK.Cg-Ay/a mice and a decrease in the number of Bifidobacterium spp. in KK.Cg-a/a mice were observed. The possibility of therapeutic use of the probiotic based on H. alvei is discussed.

Keywords: Hafnia alvei; energy metabolism; inbred mouse strains; microbiota; type 2 diabetes mellitus.

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