Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul;177(3):313-317.
doi: 10.1007/s10517-024-06180-2. Epub 2024 Aug 10.

Effect of Hafnia alvei on Morphophysiologic Parameters and Gut Microbiota of Mice with Inherited Type 2 Diabetes Mellitus

V A Zolotarev  1 , V O Murovets  2 , N S Novikova  3 , E I Ermolenko  3 , A L Sepp  2 , R P Khropycheva  2
Affiliations

Effect of Hafnia alvei on Morphophysiologic Parameters and Gut Microbiota of Mice with Inherited Type 2 Diabetes Mellitus

V A Zolotarev et al. Bull Exp Biol Med. 2024 Jul.

Abstract

Inbred mouse strains KK.Cg-a/a and KK.Cg-Ay/a known as genetic models of type 2 diabetes mellitus significantly surpassed the control strain C57BL/6J in the body weight, relative weight of extractable fat, and basal blood glucose levels. Real-timePCR of fecal samples from KK.Cg-a/a and KK.Cg-Ay/a mice revealed dysbiosis typical of type 2 diabetes mellitus in humans and animals. Long-term intragastric administration of a suspension of Hafnia alvei bacteria had no effect on the above morphometric and biochemical parameters. At the same time, recovery of the Bacteroides spp. population in KK.Cg-Ay/a mice and a decrease in the number of Bifidobacterium spp. in KK.Cg-a/a mice were observed. The possibility of therapeutic use of the probiotic based on H. alvei is discussed.

Keywords: Hafnia alvei; energy metabolism; inbred mouse strains; microbiota; type 2 diabetes mellitus.

PubMed Disclaimer

References

    1. Vallianou NG, Kounatidis D, Tsilingiris D, Panagopoulos F, Christodoulatos GS, Evangelopoulos A, Karampela I, Dalamaga M. The role of next-generation probiotics in obesity and obesity-associated disorders: current knowledge and future perspectives. Int. J. Mol. Sci. 2023;24(7):6755. https://doi.org/10.3390/ijms24076755 - DOI - PubMed - PMC
    1. Tennoune N, Chan P, Breton J, Legrand R, Chabane YN, Akkermann K, Järv A, Ouelaa W, Takagi K, Ghouzali I, Francois M, Lucas N, Bole-Feysot C, Pestel-Caron M, do Rego JC, Vaudry D, Harro J, Dé E, Déchelotte P, Fetissov SO. Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders. Transl. Psychiatry. 2014;4(10):e458. https://doi.org/10.1038/tp.2014.98
    1. Anderson EJ, Çakir I, Carrington SJ, Cone RD, Ghamari-Langroudi M, Gillyard T, Gimenez LE, Litt MJ. 60 years of POMC: regulation of feeding and energy homeostasis by α-MSH. J. Mol. Endocrinol. 2016;56(4):T157-T174. https://doi.org/10.1530/JME-16-0014 - DOI - PubMed - PMC
    1. Zolotarev VA, Murovets VO, Sepp AL, Sozontov EA, Lukina EA, Khropycheva RP, Pestereva NS, Ivleva IS, EL Mehdi M, Lahaye E, Chartrel N, Fetissov SO. Protein extract of a probiotic strain of Hafnia alvei and bacterial ClpB protein improve glucose tolerance in mice. Int. J. Mol. Sci. 2023;24(13):10590. https://doi.org/10.3390/ijms241310590 - DOI - PubMed - PMC
    1. Staats J. Standardized nomenclature for inbred strains of mice: fifth listing. Cancer Res. 1972;32(8):1609-1646. - PubMed

LinkOut - more resources