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. 2024 Aug 9;5(8):856-858.
doi: 10.1016/j.medj.2024.07.001.

Asciminib: the next-generation bullet for first-line treatment of chronic myeloid leukemia

Chikashi Yoshida  1 , Tomoiku Takaku  2
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Free article

Asciminib: the next-generation bullet for first-line treatment of chronic myeloid leukemia

Chikashi Yoshida et al. Med. .
Free article

Abstract

The standard of care for chronic myeloid leukemia (CML) involves tyrosine kinase inhibitors (TKIs), which suppress tyrosine kinase activity of BCR::ABL1. Hochhaus et al. reported that asciminib, a BCR::ABL1 inhibitor specifically targeting the ABL myristoyl pocket, showed superior efficacy and favorable safety compared with TKIs in the phase 3 ASC4FIRST trial in patients with newly diagnosed chronic-phase CML.1.

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Conflict of interest statement

Declaration of interests C.Y. received research funding from Bristol Myers Squibb. T.T. received honoraria from Novartis.

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