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. 2024 Oct;106(4):749-752.
doi: 10.1016/j.kint.2024.07.022. Epub 2024 Aug 9.

Pre-transplant anti-nephrin antibodies are specific predictors of recurrent diffuse podocytopathy in the kidney allograft

Ibrahim Batal  1 , Andrew J B Watts  2 , Jean-Baptiste Gibier  3 , Aghiles Hamroun  4 , Isabelle Top  5 , François Provot  6 , Keith Keller  7 , Xiaoyi Ye  8 , Hilda E Fernandez  9 , Rita Leal  10 , Nicole K Andeen  11 , Russell J Crew  9 , Geoffrey K Dube  9 , Elena-Rodica Vasilescu  12 , Lloyd E Ratner  13 , Nicole Bowman  2 , Andrew S Bomback  9 , Simone Sanna-Cherchi  9 , Krzysztof Kiryluk  9 , Astrid Weins  14
Affiliations

Pre-transplant anti-nephrin antibodies are specific predictors of recurrent diffuse podocytopathy in the kidney allograft

Ibrahim Batal et al. Kidney Int. 2024 Oct.
No abstract available

Keywords: anti-nephrin antibodies; diffuse podocytopathy; focal segmental glomerular sclerosis; kidney allograft; minimal change disease; recurrent disease.

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Conflict of interest statement

Disclosure statement:

A. Watts, K. Keller, and A. Weins hold a patent “PCT/US2021/056157: Methods for identifying and treating patients with antibody-mediated acquired primary or recurrent idiopathic nephrotic syndrome.” All others declare no conflicts of interest.

Figures

Figure 1:
Figure 1:. Diffuse podocytopathy recurrence–free allograft survival in patients stratified by the presence of positive circulating anti-nephrin antibodies before transplantation
P value is derived from log-rank test
Figure 2:
Figure 2:. Representative confocal microscopy images of glomeruli stained for IgG (green) and nephrin (red) in allograft biopsies of patients with native kidney failure secondary to diffuse podocytopathy (DP)
(a) Recurrent DP biopsy with punctate IgG (upper panel) overlapping with nephrin (middle and lower panel) (b) Recurrent DP biopsy with punctate IgG (upper panel) and punctate nephrin, without significant overlap (middle and lower panel) (c) Recurrent DP biopsy with negative IgG (upper panel) and punctate staining for nephrin (middle and lower panel) (d) Non-recurrent DP biopsy with negative IgG (upper panel) and continuous staining for nephrin (middle and lower panel)
See this image and copyright information in PMC

References

    1. Maas RJ, Deegens JK, Smeets B, et al. Minimal change disease and idiopathic FSGS: manifestations of the same disease. Nat Rev Nephrol 2016; 12: 768–776. - PubMed
    1. Hengel FE, Dehde S, Lasse M, et al. Autoantibodies Targeting Nephrin in Podocytopathies. N Engl J Med 2024. - PubMed
    1. Ishizuka K, Miura K, Hashimoto T, et al. Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature. Sci Rep 2021; 11: 12008. - PMC - PubMed
    1. Leca N. Focal segmental glomerulosclerosis recurrence in the renal allograft. Adv Chronic Kidney Dis 2014; 21: 448–452. - PubMed
    1. Watts AJB, Keller KH, Lerner G, et al. Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol 2022; 33: 238–252. - PMC - PubMed

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