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. 2024 May;20(3):247-254.
doi: 10.5152/iao.2024.231269.

Cervical and Ocular Vestibular Evoked Myogenic Potentials in Fibromyalgia Syndrome Patients

Abeir Osman Dabbous  1 , Noha Mahmoud Abdel Baki  2 , Malak Medhat Hassanein  1 , Sarah Mohamed Sheta  1
Affiliations

Cervical and Ocular Vestibular Evoked Myogenic Potentials in Fibromyalgia Syndrome Patients

Abeir Osman Dabbous et al. J Int Adv Otol. 2024 May.

Abstract

Background: Fibromyalgia syndrome (FMS) is a chronic pain condition that may be associated with dysfunction in the central nervous system.

Objective: The aim of this study was to assess the vestibulo-spinal reflex (VSR) and vestibulo-ocular reflex (VOR) in FMS using the cervical vestibular evoked myogenic potential (cVEMP) and ocular vestibular evoked myogenic potential (oVEMP) tests, respectively, and to evaluate their relation to disease severity.

Methods: This study included 30 female FMS patients and 30 well-matched healthy controls. They underwent full history taking and assessment of the severity of dizziness/vertigo using the Dizziness Handicap Inventory; assessment of the severity of FMS symptoms using the Revised Fibromyalgia Impact Questionnaire; bedside examination of the dizzy patient; videonystagmography, cVEMP, and oVEMP tests; basic audiologic evaluation; and uncomfortable loudness level (UCL) testing.

Results: Dizziness was reported in 46.6% and vertigo in 11.1% of patients. Abnormalities in cVEMP (50%) and oVEMP (63.3%) were mostly unilateral, irrespective of FMS severity. Disease duration affected only the oVEMP amplitude. Fibromyalgia syndrome patients had a statistically significant lower UCL and narrower dynamic range compared to controls.

Conclusion: The VSR and VOR are commonly affected in FMS patients, and findings suggest central sensitization involving the brain stem. We recommend routine cVEMP and oVEMP testing to assess brainstem function in FMS patients.

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Conflict of interest statement

Declaration of Interests: The authors have no conflicts of interest to declare.

References

    1. Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014;311(15):1547 1555. (10.1001/jama.2014.3266) - DOI - PubMed
    1. Peinado-Rubia A, Osuna-Pérez MC, Rodríguez-Almagro D, Zagalaz-Anula N, López-Ruiz MC, Lomas-Vega R. Impaired balance in patients with fibromyalgia syndrome: predictors of the impact of this disorder and balance confidence. Int J Environ Res Public Health. 2020;17(9):3160. (10.3390/ijerph17093160) - DOI - PMC - PubMed
    1. Gilliland BC. Fibromyalgia, arthritis associated with systemic disease, and other arthritides. In: Kasper D. L., Harrison T. R., eds. Harrison’s Principles of Internal Medicine, Vol 2, 16th edn. New York, NY, USA: McGraw-Hill, Medical Publication Division; 2005: 2055 2064.
    1. Bohn D, Bernardy K, Wolfe F, Häuser W. The association among childhood maltreatment, somatic symptom intensity, depression, and somatoform dissociative symptoms in patients with fibromyalgia syndrome: a single-center cohort study. J Trauma Dissociation. 2013;14(3):342 358. (10.1080/15299732.2012.736930) - DOI - PubMed
    1. Rosengren SM, Colebatch JG, Young AS, Govender S, Welgampola MS. Vestibular evoked myogenic potentials in practice: methods, pitfalls and clinical applications. Clin Neurophysiol Pract. 2019;4(4):47 68. (10.1016/j.cnp.2019.01.005) - DOI - PMC - PubMed

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