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. 2024 Aug 11;24(1):811.
doi: 10.1186/s12879-024-09716-z.

The spatial-temporal distribution of hepatitis B virus infection in China,2006-2018

Liping Jiao  1 , Tuo Shen  2 , Yingzi Han  1 , Wen Liu  3 , Wei Liu  1 , Lin Dang  1 , Mingmin Wei  1 , Yunyun Yang  1 , Jingjing Guo  1 , Meirong Miao  1 , Xiangming Xu  1
Affiliations

The spatial-temporal distribution of hepatitis B virus infection in China,2006-2018

Liping Jiao et al. BMC Infect Dis. .

Erratum in

Abstract

Objectives: Hepatitis B is a liver disease caused by Hepatitis B virus (HBV) infection and is highly prevalent in China. To better understand the epidemiological characteristics of hepatitis B in China and develop effective disease control strategies, we employed temporal and spatial statistical methods.

Methods: We obtained HBV incidence data from the Public Health Science Data Center of the Chinese Center for Disease Control and Prevention for the years 2006 to 2018. Using Geographic Information System (GIS) and SaTScan scanning technology, we conducted spatial autocorrelation analysis and spatiotemporal scan analysis to create a map and visualize the distribution of hepatitis B incidence.

Results: While hepatitis B incidence rebounded in 2011 and 2017, the overall incidence in China decreased.In the trend analysis by item, the incidence varies from high to low. The global spatial autocorrelation analysis revealed a clustered distribution, and the Moran index analysis of spatial autocorrelation within local regions identified five provinces as H-H clusters (hot spots), while one province was an L-L cluster (cold spot). Spatial scan analysis identified 11 significant spatial clusters.

Conclusions: We found significant clustering in the spatial distribution of hepatitis B incidence and positive spatial correlation of hepatitis B incidence in China. We also identified high-risk times and regional clusters of hepatitis B incidence.

Keywords: Cluster; Geographic information system; Hepatitis B infection; Moran’s I; Spatial epidemiology; Time-spatial distribution.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1A
Fig. 1A
Number of reported cases of hepatitis B by province, 2006–2018
Fig. 1B
Fig. 1B
Number of provinces with more than 100/100,000 hepatitis B prevalence and hepatitis B incidence rates per 100,000 habitants reported in China during 2006–2018 period. The plotted points correspond to incidence rates and the lines consist in short term trends
Fig. 2A
Fig. 2A
Analysis of the incidence of hepatitis B by season from 2006 to 2018
Fig. 2B
Fig. 2B
Analysis of the incidence of hepatitis B by age group from 2006 to 2018
Fig. 2C
Fig. 2C
Analysis of the incidence of hepatitis B by geographic region from 2006 to 2018
Fig. 3
Fig. 3
Distribution of annual hepatitis B incidence rates in different provinces in China from 2006 to 2018
Fig. 4
Fig. 4
Annual spatial clustering map for hepatitis B from 2006 to 2018
Fig. 5
Fig. 5
Annual satscan cluster analysis of hepatitis B from 2006 to 2018
Fig. 6A
Fig. 6A
Hepatitis B cold hotspot analysis between 2006 and 2018
Fig. 6B
Fig. 6B
Hepatitis B spatiotemporal clustering analysis between 2006 and 2018
See this image and copyright information in PMC

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References

    1. Ganem D, Prince AM. Hepatitis B virus infection–natural history and clinical consequences. N Engl J Med. 2004;350(11):1118–29. - PubMed
    1. Ginzberg D. Global HBV burden: guesstimates and facts. Hep Intl 2018, 12(4). - PubMed
    1. Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151–71. - PubMed
    1. Than TT, Jo E, Todt D, Nguyen PH, Steinmann J, Steinmann E, Windisch MP. High environmental stability of hepatitis B virus and inactivation requirements for chemical biocides. J Infect Dis. 2019;219(7):1044–8. - PMC - PubMed
    1. Yang S, Zeng W, Zhang J, Lu F, Chang J, Guo J-T. Restoration of a functional antiviral immune response to chronic HBV infection by reducing viral antigen load: if not sufficient, is it necessary? Emerg Microbes Infections. 2021;10(1):1545–54. - PMC - PubMed

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