Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov 7;2(6Part A):101069.
doi: 10.1016/j.jscai.2023.101069. eCollection 2023 Nov-Dec.

Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Lesions: Long-Term Sex-Specific Outcomes

Jennifer Frampton  1 , Kathleen E Kearney  2 , J Dawn Abbott  3 , Dean J Kereiakes  4 , Carlo Di Mario  5 , Shigeru Saito  6 , Ecaterina Cristea  1 , Robert F Riley  7 , Jean Fajadet  8 , Richard A Shlofmitz  9 , Ziad A Ali  10 , Andrew J Klein  11 , Matthew J Price  12 , Jonathan M Hill  13 , Gregg W Stone  14 , Alexandra J Lansky  1
Affiliations

Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Lesions: Long-Term Sex-Specific Outcomes

Jennifer Frampton et al. J Soc Cardiovasc Angiogr Interv. .

Erratum in

  • Correction.
    [No authors listed] [No authors listed] J Soc Cardiovasc Angiogr Interv. 2025 Aug 9;4(10Part A):103930. doi: 10.1016/j.jscai.2025.103930. eCollection 2025 Oct. J Soc Cardiovasc Angiogr Interv. 2025. PMID: 41268087 Free PMC article.

Abstract

Background: Intravascular lithotripsy (IVL) for calcified lesion preparation prior to drug-eluting stent placement has high procedural success and safety, especially in women, whereas other atheroablative approaches are associated with increased procedural complications. We sought to investigate long-term sex-based outcomes of IVL-facilitated stenting.

Methods: We performed a patient-level pooled analysis of the single-arm Disrupt CAD III and IV studies. Patient baseline, procedural characteristics, and outcomes were examined according to sex at 30 days and 1 year. The primary end point was major adverse cardiac events (a composite of cardiac death, all myocardial infarction, or target vessel revascularization). Target lesion failure was defined as cardiac death, target vessel myocardial infarction, or ischemia-driven target lesion revascularization.

Results: A total of 448 patients, 106 (24%) women, were included. Women were older and less likely to be smokers. Women had smaller reference vessel diameters (2.8 mm vs 3.1 mm), shorter lesion length (23.6 mm vs 27.1 mm), and shorter total calcified length (44.4 mm vs 49.3 mm) compared with men. Post-IVL angiographic outcomes and complications were similar between women and men. At 1 year, major adverse cardiac event rates (12.3% vs 13.2%, P = .52) were not different between women and men. There were no differences between women and men (10.4% vs 11.2%; P = .43) in target lesion failure at 1 year.

Conclusions: Use of IVL in the treatment of severely calcified lesions is associated with low rates of adverse clinical events and with similar safety and effectiveness in women and men at 1 year.

Keywords: calcification; coronary artery disease; drug-eluting stent; intravascular lithotripsy; sex.

PubMed Disclaimer

Figures

None
Graphical abstract
Figure 1
Figure 1
Patient flow diagram. ITT, intention-to-treat.
Central Illustration
Central Illustration
One-year outcomes of IVL-facilitated stenting of severely calcified coronary lesions according to sex. IVL, intravascular lithotripsy; MACE, major adverse cardiac event; TLF, target lesion failure.
See this image and copyright information in PMC

References

    1. Kobayashi Y., Okura H., Kume T., et al. Impact of target lesion coronary calcification on stent expansion. Circ J. 2014;78(9):2209–2214. - PubMed
    1. Choi K.H., Song Y.B., Lee J.M., et al. Impact of intravascular ultrasound-guided percutaneous coronary intervention on long-term clinical outcomes in patients undergoing complex procedures. J Am Coll Cardiol Intv. 2019;12(7):607–620. - PubMed
    1. Bangalore S., Vlachos H.A., Selzer F., et al. Percutaneous coronary intervention of moderate to severe calcified coronary lesions: insights from the National Heart, Lung, and Blood Institute Dynamic Registry. Catheter Cardiovasc Interv. 2011;77(1):22–28. - PMC - PubMed
    1. Généreux P., Madhavan M.V., Mintz G.S., et al. Ischemic outcomes after coronary intervention of calcified vessels in acute coronary syndromes. Pooled analysis from the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) TRIALS. J Am Coll Cardiol. 2014;63(18):1845–1854. - PubMed
    1. Madhavan M.V., Tarigopula M., Mintz G.S., Maehara A., Stone G.W., Généreux P. Coronary artery calcification: pathogenesis and prognostic implications. J Am Coll Cardiol. 2014;63(17):1703–1714. - PubMed

LinkOut - more resources