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Case Reports
. 2024 Jul 10;16(7):e64283.
doi: 10.7759/cureus.64283. eCollection 2024 Jul.

Corneal Deposits Following Combined Gatifloxacin and Prednisolone Therapy Post-Keratoplasty: A Report of a Rare Case

Chaitanya Modgil  1 , Pranav More  2 , Abhay Lune  1 , Iqra Mushtaq  1
Affiliations
Case Reports

Corneal Deposits Following Combined Gatifloxacin and Prednisolone Therapy Post-Keratoplasty: A Report of a Rare Case

Chaitanya Modgil et al. Cureus. .

Abstract

Corneal deposits associated with topical medications, particularly fluoroquinolones, are a recognized complication in ophthalmic practice. We present a case of a 66-year-old female with pseudophakic bullous keratopathy who developed corneal crystalline deposits following prolonged use of gatifloxacin and prednisolone eye drops post-penetrating keratoplasty. The patient presented with diminished vision and significant corneal opacity in the affected eye. Anterior segment examination and OCT imaging confirmed deposits extending from the epithelium to the anterior stroma. Management included corneal scrapping and transition to topical tobramycin and propylene glycol eye drops, resulting in the resolution of deposits and improvement in vision. This case underscores the importance of vigilant monitoring and judicious use of topical medications to mitigate adverse effects in high-risk ophthalmic patients undergoing corneal procedures.

Keywords: corneal deposit; corneal scrapping; gatifloxacin; keratoplasty; prednisolone.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Anterior segment of the left eye showing crystalline deposits over the cornea, with 16 intact sutures and a healthy graft and suture site.
Figure 2
Figure 2. Anterior segment OCT of the left cornea showing corneal deposits involving the epithelium till the anterior stroma.
OCT, Optical Coherence Tomography
Figure 3
Figure 3. Cornea with clearing of the central area after scrapping of deposits with a 15-number blade.
Figure 4
Figure 4. Sequence of surgical interventions, medications, and adverse events.
Image credit: Chaitanya Modgil.
See this image and copyright information in PMC

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