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. 2022 Apr 15;1(4):618-626.
doi: 10.1016/j.gastha.2022.04.007. eCollection 2022.

Worldwide Incidence and Mortality of Biliary Tract Cancer

Katherine Baria  1 , Enrico N De Toni  2 , Binbing Yu  3 , Zhuoxin Jiang  4 , Shaum M Kabadi  4 , Matteo Malvezzi  5
Affiliations

Worldwide Incidence and Mortality of Biliary Tract Cancer

Katherine Baria et al. Gastro Hep Adv. .

Abstract

Background and aims: Biliary tract cancer (BTC) consists of a group of hepatic and perihepatic tumors that are in close proximity but are anatomically different, including gallbladder cancer (GBC), cholangiocarcinoma (extrahepatic and intrahepatic [ICC]), and ampulla of Vater cancer (AVC). Most epidemiologic research has focused on 1 or more anatomic subtypes, or does not differentiate BTC from hepatocellular carcinoma or other primary liver cancers. Here, we provide a descriptive update on global incidence and mortality rates for BTC, overall and by anatomic subtypes.

Methods: Age-standardized rates (per 100,000 person-years) were derived from the International Agency for Research on Cancer, Cancer Incidence in Five Continents, Volume XI (2008-2012; 22 countries), and the World Health Organization Mortality Database (2006-2016; 38 countries).

Results: BTC incidence varied by country, with the highest in Chile (14.35) and the lowest in Vietnam (1.25). Mortality rates for BTC were highest for the Republic of Korea (11.64) and lowest for the Republic of Moldova (1.65). BTC mortality rates increased over time in 24 of 34 countries. Patients aged ≥75 years had 5-10 times higher mortality rates than the overall BTC rate in all countries. In most countries, incidence rates were highest for GBC, and mortality rates highest for ICC, while both were lowest for AVC. Females had and died from GBC more frequently than males. For ICC, extrahepatic cholangiocarcinoma, and AVC, males trended toward higher incidence and mortality rates.

Conclusion: The increasing incidence and mortality trends reported here indicate a need for improved prevention and treatment for all BTC subtypes.

Keywords: Biliary Tract Neoplasms; Epidemiological Studies; Patient-Focused Care; Public Health.

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Figures

Figure 1
Figure 1
Incidence of BTC (A) overall and (B) for subtypes, by country, from 2008 to 2012. ASR, age-standardized rate; AVC, ampulla of Vater Cancer; BTC, biliary tract cancer; ECC, extrahepatic cholangiocarcinoma; GBC, gallbladder cancer; ICC, intrahepatic cholangiocarcinoma; NOS, not otherwise specified.
Figure 2
Figure 2
Mortality rates for BTC (A) overall, (B) overall in patients aged >75 years, and (C) for subtypes, by country, from 2006 to 2016. ASR, age-standardized rate; AVC, ampulla of Vater Cancer; BTC, biliary tract cancer; ECC, extrahepatic cholangiocarcinoma; GBC, gallbladder cancer; ICC, intrahepatic cholangiocarcinoma; NOS, not otherwise specified.
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