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Case Reports
. 1979 Oct 13;2(6195):898-9.
doi: 10.1136/bmj.2.6195.898.

Immunological effect of co-trimoxazole on platelets

F H Claas, J W van der Meer, J Langerak
Case Reports

Immunological effect of co-trimoxazole on platelets

F H Claas et al. Br Med J. .

Abstract

Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance.

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