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Review
. 2024 Jul 26:14:1337815.
doi: 10.3389/fonc.2024.1337815. eCollection 2024.

Genetic profiling in radiotherapy: a comprehensive review

Dino Rubini  1 , Federico Gagliardi  1 , Vittorio Salvatore Menditti  1 , Luca D'Ambrosio  1 , Paolo Gallo  1 , Ida D'Onofrio  1 , Antonio Rosario Pisani  2 , Angela Sardaro  2 , Giuseppe Rubini  2 , Salvatore Cappabianca  1 , Valerio Nardone #  1 , Alfonso Reginelli #  1
Affiliations
Review

Genetic profiling in radiotherapy: a comprehensive review

Dino Rubini et al. Front Oncol. .

Abstract

This comprehensive review explores the pivotal role of radiotherapy in cancer treatment, emphasizing the diverse applications of genetic profiling. The review highlights genetic markers for predicting radiation toxicity, enabling personalized treatment planning. It delves into the impact of genetic profiling on radiotherapy strategies across various cancer types, discussing research findings related to treatment response, prognosis, and therapeutic resistance. The integration of genetic profiling is shown to transform cancer treatment paradigms, offering insights into personalized radiotherapy regimens and guiding decisions in cases where standard protocols may fall short. Ultimately, the review underscores the potential of genetic profiling to enhance patient outcomes and advance precision medicine in oncology.

Keywords: genomic profiling; profiling; radiation oncology (RO); radiogenomics; radiotherapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

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