Clinical Trial

. 2024 Aug 13;150(7):580-582.

doi: 10.1161/CIRCULATIONAHA.124.069396. Epub 2024 Aug 12.

Results of International, Double-Blind, Randomized, Placebo-Controlled, Phase IIa Study of Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment-Elevation Myocardial Infarction (STEMI)

Collaborators, Affiliations

Collaborators

RPH-104 STEMI Study Investigators:
Alexandra Pisaryuk, Lala Babaeva, Ilya Zyuryaev, Denis Kalimulin, Oleg Lapin, Sergei Mekhriakov, Nikolay Popov, Igor Kalashnikov, Ekaterina Duhanina, Samra Osmanova, Egor Kornilov, Ekaterina Zubova, Vakhtang Safarian, Natalia Selezneva, Ekaterina Savelieva, Olga Privalova, Zaur Shogenov, Vladimir Novosadov, Murat Agirov, Rostislav Nilk, Andrey Fedash, Andrey Yurkovskiy, Anastasia Kotova, Ilya Staroverov, Vyacheslav Mayorov, Oxana Lonchakova, Denis Rozanov, Sergey Yakushin, Sergey Seleznev, Ekaterina Pravkina, Kristina Pereverzeva, Galina Ivanova, Jeremy S Turlington, Georgia Thomas, Azita H Talasaz, Michele Golino, Marco Giuseppe Del Buono, Amr Marawan, Juan Ignacio Damonte

Affiliations

¹ Department of Medicine, University of Virginia, Charlottesville (A.A., A.T.).
² Department of Internal Medicine, Virginia Commonwealth University, Richmond (B.V.T., R.M.).
³ Cromos Pharma, LLC, Portland, OR (V.B.).
⁴ Emergency Cardiology Department, National Medical Research Center for Cardiology of the Ministry of Healthcare of the Russian Federation, Moscow, Russia (D.V. Pevzner).
⁵ Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (P.C.C.).
⁶ Department of Internal Medicine, Peoples' Friendship University of Russia n.a. Patrice Lumumba, Moscow (I.M.).
⁷ Cardiology and Intensive Therapy Department, City Clinical Hospital No. 51 of Moscow Healthcare Department, Russia (D.V. Privalov).
⁸ R-Pharm JSC, Medical Department, Moscow, Russia (S.A.G., A.N.E., E.G.P., M.Y.S.).
⁹ R-Pharm Overseas Inc, La Jolla, CA (Y.L.).

PMID: 39133774
DOI: 10.1161/CIRCULATIONAHA.124.069396

Clinical Trial

Results of International, Double-Blind, Randomized, Placebo-Controlled, Phase IIa Study of Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment-Elevation Myocardial Infarction (STEMI)

Antonio Abbate et al. Circulation. 2024.

. 2024 Aug 13;150(7):580-582.

doi: 10.1161/CIRCULATIONAHA.124.069396. Epub 2024 Aug 12.

Authors

Collaborators

RPH-104 STEMI Study Investigators:
Alexandra Pisaryuk, Lala Babaeva, Ilya Zyuryaev, Denis Kalimulin, Oleg Lapin, Sergei Mekhriakov, Nikolay Popov, Igor Kalashnikov, Ekaterina Duhanina, Samra Osmanova, Egor Kornilov, Ekaterina Zubova, Vakhtang Safarian, Natalia Selezneva, Ekaterina Savelieva, Olga Privalova, Zaur Shogenov, Vladimir Novosadov, Murat Agirov, Rostislav Nilk, Andrey Fedash, Andrey Yurkovskiy, Anastasia Kotova, Ilya Staroverov, Vyacheslav Mayorov, Oxana Lonchakova, Denis Rozanov, Sergey Yakushin, Sergey Seleznev, Ekaterina Pravkina, Kristina Pereverzeva, Galina Ivanova, Jeremy S Turlington, Georgia Thomas, Azita H Talasaz, Michele Golino, Marco Giuseppe Del Buono, Amr Marawan, Juan Ignacio Damonte

Affiliations

¹ Department of Medicine, University of Virginia, Charlottesville (A.A., A.T.).
² Department of Internal Medicine, Virginia Commonwealth University, Richmond (B.V.T., R.M.).
³ Cromos Pharma, LLC, Portland, OR (V.B.).
⁴ Emergency Cardiology Department, National Medical Research Center for Cardiology of the Ministry of Healthcare of the Russian Federation, Moscow, Russia (D.V. Pevzner).
⁵ Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (P.C.C.).
⁶ Department of Internal Medicine, Peoples' Friendship University of Russia n.a. Patrice Lumumba, Moscow (I.M.).
⁷ Cardiology and Intensive Therapy Department, City Clinical Hospital No. 51 of Moscow Healthcare Department, Russia (D.V. Privalov).
⁸ R-Pharm JSC, Medical Department, Moscow, Russia (S.A.G., A.N.E., E.G.P., M.Y.S.).
⁹ R-Pharm Overseas Inc, La Jolla, CA (Y.L.).

PMID: 39133774
DOI: 10.1161/CIRCULATIONAHA.124.069396

No abstract available

Keywords: cytokine; inflammation; myocardial infarction.

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Conflict of interest statement

The authors listed the following disclosures: A.A., Implicit Biosciences and Kiniksa Pharmaceuticals (consulting); B.V.T., Implicit Bioscience LLC (consulting), R-Pharm, NovoNordisk, abd Novartis (research grant); V.B., Cromos Pharma (owner); D.V. Pevsner, Boston Scientific (consulting, research grant, lectures fee), R-Pharm (research grant), Novartis (research grant, travel grant); P.C.C., SOBI, Kiniksa, and CardiolRx (consulting), Kiniksa and Novartis (research grant); D.V. Privalov, R-Pharm, Covance (EMPACT–MI), CSL Behring LLC (AEGIS-II—research grant); A.T., Boston Scientific (medical advisory board and consultant); S.A.G., R-Pharm (employee); A.N.E., R-Pharm (employee); E.G.P., R-Pharm (employee); Y.L., R-Pharm Overseas, Inc (employee); M.Y.S., R-Pharm (employee). The other authors report no conflicts.

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Results of International, Double-Blind, Randomized, Placebo-Controlled, Phase IIa Study of Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment-Elevation Myocardial Infarction (STEMI)

Collaborators

Affiliations

Results of International, Double-Blind, Randomized, Placebo-Controlled, Phase IIa Study of Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment-Elevation Myocardial Infarction (STEMI)

Authors

Collaborators

Affiliations

Conflict of interest statement

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources

Full Text Sources

Medical