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. 2024 Oct;17(10):e202400124.
doi: 10.1002/jbio.202400124. Epub 2024 Aug 12.

Effect of photobiomodulation in an experimental in vitro model of asthma-Copd overlap

Marina Bertoni Guerra  1 , Kelly Gomes Santana  1 , Marcos Momolli  1 , Rodrigo Labat  1 , Maria Cristina Chavantes  2 , Stella Regina Zammuner  1   2 , José Antonio Silva Júnior  1   2 , Renata Kelly da Palma  3 , Flavio Aimbire  4 , Ana Paula Ligeiro de Oliveira  1
Affiliations

Effect of photobiomodulation in an experimental in vitro model of asthma-Copd overlap

Marina Bertoni Guerra et al. J Biophotonics. 2024 Oct.

Abstract

The objective of the study was to evaluate the effect of photobiomodulation (PBM) with laser on the inflammatory process in an experimental in vitro model of ACO. The groups were: (1) human bronchial epithelial cells (BEAS-2B); (2) BEAS-2B cells treated with dexamethasone; (3) BEAS-2B cells irradiated with laser; (4) BEAS-2B cells stimulated with cigarette smoke extract (CSE) + House Dust Mite (HDM); (5) BEAS-2B cells stimulated with CSE + HDM and treated with dexamethasone; (6) BEAS-2B cells incubated with CSE + HDM and irradiated with laser. After 24 h, cytokines were quantified. There was a reduction in TNF-α, IL-1β, IL-6, IL-4, IL-5, IL-13, IL-17, IL-21, IL-23, and an increase in IL-10 and IFN-γ in cells from the laser-irradiated ACO group compared to only ACO group. With these results, we can suggest that photobiomodulation acts in the modulation of inflammation observed in ACO, and may be a treatment option.

Keywords: asthma‐COPD overlap; cytokines; low level laser; photobiomodulation.

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