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. 2024 Nov;31(11):775-779.
doi: 10.1111/jvh.13995. Epub 2024 Aug 12.

Mixed-Genotype HCV Direct Acting Antiviral Outcomes: A CANUHC Analysis

Haris Imsirovic  1 , Gisela Macphail  2 , Brian Conway  3 , Chris Fraser  4 , Sergio Borgia  5   6 , Daniel Smyth  7 , Alexander Wong  8 , Marie-Louise Vachon  9 , Duncan Webster  7 , Hongqun Liu  2 , Jordan Feld  10 , Sam Lee  2 , Curtis Cooper  1   11 ; Canadian Network Undertaking against Hepatitis C (CANUHC) Cohort Investigator Team
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Mixed-Genotype HCV Direct Acting Antiviral Outcomes: A CANUHC Analysis

Haris Imsirovic et al. J Viral Hepat. 2024 Nov.

Abstract

The prevalence of mixed hepatitis C virus (HCV) genotype infection in a representative Canadian HCV cohort is reported and virological response with direct acting antiviral (DAA) treatment was evaluated. 3272 HCV-positive participants were enrolled, of which 2945 (90.0%) initiated DAA therapy. 0.8% were identified with mixed genotype infection. Overall sustained virological response (SVR) was 99.1% and did not differ based on mixed genotype status. Any historical disadvantage to achieving cure with HCV treatment in mixed genotype infection has been overcome by current DAA regimens.

Keywords: direct acting antivirals; hepatitis C; mixed genotypes; outcomes.

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References

    1. L. B. Seeff, “Natural History of Chronic Hepatitis C,” Hepatology 36, no. 5 Suppl 1 (2002): S35–S46.
    1. GBD Disease and Injury Incidence and Prevalence Collaborators, “Global, Regional, and National Incidence, Prevalence, and Years Lived With Disability for 310 Diseases and Injuries, 1990‐2015: A Systematic Analysis for the Global Burden of Disease Study 2015,” Lancet 388, no. 10053 (2016): 1545–1602.
    1. World Health Organization, Hepatitis C. accessed May 9, 2024, vol: 9, Fact Sheets Web site: https://www.who.int/en/news‐room/fact‐sheets/detail/hepatitis‐c 2024.
    1. World Health Organization, Global Hepatitis Report 2024: Action for Access in low‐ and Middle‐Income Countries (Geneva: World Health Organization, 2024).
    1. Public Health Agency of Canada, “Report on Hepatitis B and C Surveillance in Canada: 2019,” in Control TCfCDaI (Ottawa, Canada: Government of Canada, 2022).

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